8.A.23.1.14
Coxsackievirus and adenovirus receptor, CAR, of 365 aas and 2 TMSs near the N- and C-termini. It is a component of the epithelial apical junction
complex that may function as a homophilic cell adhesion molecule and is
essential for tight junction integrity. It is also involved in transepithelial
migration of leukocytes through adhesive interactions with JAML, a
transmembrane protein of the plasma membrane of leukocytes (Cohen et al. 2001). It's subcellular distribution has been studied (Ifie et al. 2018). The CAR in zebrafish (Q90Y50) has been discussed (Rathjen 2020).
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| Accession Number: | P78310 |
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| Protein Name: | Coxsackievirus and adenovirus receptor |
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| Length: | 365 |
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| Molecular Weight: | 40030.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MALLLCFVLL CGVVDFARSL SITTPEEMIE KAKGETAYLP CKFTLSPEDQ GPLDIEWLIS
61: PADNQKVDQV IILYSGDKIY DDYYPDLKGR VHFTSNDLKS GDASINVTNL QLSDIGTYQC
121: KVKKAPGVAN KKIHLVVLVK PSGARCYVDG SEEIGSDFKI KCEPKEGSLP LQYEWQKLSD
181: SQKMPTSWLA EMTSSVISVK NASSEYSGTY SCTVRNRVGS DQCLLRLNVV PPSNKAGLIA
241: GAIIGTLLAL ALIGLIIFCC RKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS
301: SLGSMSPSNM EGYSKTQYNQ VPSEDFERTP QSPTLPPAKV AAPNLSRMGA IPVMIPAQSK
361: DGSIV