8.A.23.1.18
Tex14 of 1497 aas and 1 or 2 TMSs. Required both for the formation of
intercellular bridges during meiosis and for kinetochore-microtubule
attachment during mitosis. Intercellular bridges, called 'ring canals', probably result from nurse cell fusion with the developing oocyte. They are evolutionarily
conserved structures that connect differentiating germ cells and are
required for spermatogenesis, oogenesis and male fertility. They act by promoting the
conversion of midbodies into intercellular bridges via its interaction
with CEP55. Interaction with CEP55 inhibits the interaction between
CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading
to transformation of midbodies into intercellular bridges. In spite of its PK domain, it has no protein kinase activity in vitro (Lei and Spradling 2016).
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| Accession Number: | Q8IWB6 |
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| Protein Name: | Inactive serine/threonine-protein kinase TEX14 |
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| Length: | 1497 |
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| Molecular Weight: | 167901.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MSRAVRLPVP CPVQLGTLRN DSLEAQLHEY VKQGNYVKVK KILKKGIYVD AVNSLGQTAL
61: FVAALLGLRK FVDVLVDYGS DPNHRCFDGS TPVHAAAFSG NQWILSKLLD AGGDLRLHDE
121: RGQNPKTWAL TAGKERSTQI VEFMQRCASH MQAIIQGFSY DLLKKIDSPQ RLVYSPSWCG
181: GLVQGNPNGS PNRLLKAGVI SAQNIYSFGF GKAMPWFQFY LTGATQMAYL GSLPVIGEKE
241: VIQADDEPTF SFFSGPYMVM TNLVWNGSRV TVKELNLPTH PHCSRLRLAD LLIAEQEHSS
301: KLRHPYLLQL MAVCLSQDLE KTRLVYERIT IGTLFSVLHE RRSQFPVLHM EVIVHLLLQI
361: SDALRYLHFQ GFIHRSLSSY AVHIISPGEA RLTNLEYMLE SEDRGVQRDL TRVPLPTQLY
421: NWAAPEVILQ KAATVKSDIY SFSMIMQEIL TDDIPWKGLD GSVVKKAVVS GNYLEADVRL
481: PKPYYDIVKS GIHVKQKDRT MNLQDIRYIL KNDLKDFTGA QRTQPTESPR VQRYGLHPDV
541: NVYLGLTSEH PRETPDMEII ELKEMGSQPH SPRVHSLFTE GTLDPQAPDP CLMARETQNQ
601: DAPCPAPFMA EEASSPSTGQ PSLCSFEINE IYSGCLILED DIEEPPGAAS SLEADGPNQV
661: DELKSMEEEL DKMEREACCF GSEDESSSKA ETEYSFDDWD WQNGSLSSLS LPESTREAKS
721: NLNNMSTTEE YLISKCVLDL KIMQTIMHEN DDRLRNIEQI LDEVEMKQKE QEERMSLWAT
781: SREFTNAYKL PLAVGPPSLN YIPPVLQLSG GQKPDTSGNY PTLPRFPRML PTLCDPGKQN
841: TDEQFQCTQG AKDSLETSRI QNTSSQGRPR ESTAQAKATQ FNSALFTLSS HRQGPSASPS
901: CHWDSTRMSV EPVSSEIYNA ESRNKDDGKV HLKWKMEVKE MAKKAATGQL TVPPWHPQSS
961: LTLESEAENE PDALLQPPIR SPENTDWQRV IEYHRENDEP RGNGKFDKTG NNDCDSDQHG
1021: RQPRLGSFTS IRHPSPRQKE QPEHSEAFQA SSDTLVAVEK SYSHQSMQST CSPESSEDIT
1081: DEFLTPDGEY FYSSTAQENL ALETSSPIEE DFEGIQGAFA QPQVSGEEKF QMRKILGKNA
1141: EILPRSQFQP VRSTEDEQEE TSKESPKELK EKDISLTDIQ DLSSISYEPD SSFKEASCKT
1201: PKINHAPTSV STPLSPGSVS SAASQYKDCL ESITFQVKTE FASCWNSQEF IQTLSDDFIS
1261: VRERAKKLDS LLTSSETPPS RLTGLKRLSS FIGAGSPSLV KACDSSPPHA TQRRSLPKVE
1321: AFSQHHIDEL PPPSQELLDD IELLKQQQGS STVLHENTAS DGGGTANDQR HLEEQETDSK
1381: KEDSSMLLSK ETEDLGEDTE RAHSTLDEDL ERWLQPPEES VELQDLPKGS ERETNIKDQK
1441: VGEEKRKRED SITPERRKSE GVLGTSEEDE LKSCFWKRLG WSESSRIIVL DQSDLSD