TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.23.1.19
The Advanced glycosylation end product-specific receptor of 404 aas and 2 TMSs, N- and C-terminal, AGER or RAGE.  It is the receptor for amyloid beta peptide, and it contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.  RAGE also has a number of other functions (Fang et al. 2010;.Jin et al. 2011). It's structure is known to 1.5 Å resolution (Park et al. 2010; Xue et al. 2011). ;

Accession Number:Q15109
Protein Name:Advanced glycosylation end product-specific receptor
Length:404
Molecular Weight:42803.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
2E5E   2ENS   2L7U   2LE9   2LMB   2M1K   2MJW   2MOV   3CJJ   3O3U   [...more]

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA 
61:	WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI 
121:	PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH 
181:	PETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL 
241:	VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS 
301:	CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG LGTAALLIGV 
361:	ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS TGGP