8.A.23.1.19
The Advanced glycosylation end product-specific receptor of 404 aas and 2 TMSs, N- and C-terminal, AGER or RAGE.  It is the receptor for amyloid beta peptide, and it contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.  RAGE also has a number of other functions (Fang et al. 2010;.Jin et al. 2011). It's structure is known to 1.5 Å resolution (Park et al. 2010; Xue et al. 2011).  RAGE is a transmembrane receptor of the immunoglobulin family that can bind various endogenous and exogenous ligands, initiating the inflammatory downstream signaling pathways, including inflammaging (Dascalu et al. 2024). ;