8.A.23.1.32 Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family-6, SlamF6, of 351 aas and possibly 3 TMSs, two near the N-terminus, and one near the C-terminus (Togni et al. 2004). SLAM receptors, triggered by homo- or heterotypic
cell-cell interactions, modulate the activation and differentiation
of a wide variety of immune cells and thus are involved in the
regulation and interconnection of both innate and adaptive immune
responses (Griewank et al. 2007).
|
Accession Number: | Q9ET39 |
Protein Name: | SLAM family member 6 |
Length: | 351 |
Molecular Weight: | 38638.00 |
Species: | Mus musculus (Mouse) [10090] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
Substrate |
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1: MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA VLPLKLPAGK
61: IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL NITQSYSLQI SNLTMADTGS
121: YTAQITTKDS EVITFKYILR VFERLGNLET TNYTLLLENG TCQIHLACVL KNQSQTVSVE
181: WQATGNISLG GPNVTIFWDP RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA
241: VWFMTTISII SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR
301: PMQEMKIPKP IKNDSMTIYS IVNHSREETV ALTGYNQPIT LKVNTLINYN S