8.A.23.1.34
Signal-regulatory protein beta-1, SIRPbeta (SIRPβ) of 398 aas and 2 TMSs, N- and C-terminal. It is an immunoglobulin-like cell surface receptor involved
in the negative regulation of receptor tyrosine kinase-coupled
signaling processes, and it participates in the recruitment of tyrosine
kinase SYK. It triggers activation of myeloid cells when associated with
TYROBP (Dietrich et al. 2000). Positive regulation of phagocytosis by SIRPbeta has been demonstrated as part of its signaling mechanism in macrophages (Hayashi et al. 2004).
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| Accession Number: | O00241 |
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| Protein Name: | Signal-regulatory protein beta-1 |
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| Length: | 398 |
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| Molecular Weight: | 43211.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MPVPASWPHL PSPFLLMTLL LGRLTGVAGE DELQVIQPEK SVSVAAGESA TLRCAMTSLI
61: PVGPIMWFRG AGAGRELIYN QKEGHFPRVT TVSELTKRNN LDFSISISNI TPADAGTYYC
121: VKFRKGSPDD VEFKSGAGTE LSVRAKPSAP VVSGPAVRAT PEHTVSFTCE SHGFSPRDIT
181: LKWFKNGNEL SDFQTNVDPA GDSVSYSIHS TARVVLTRGD VHSQVICEIA HITLQGDPLR
241: GTANLSEAIR VPPTLEVTQQ PMRAENQANV TCQVSNFYPR GLQLTWLENG NVSRTETAST
301: LIENKDGTYN WMSWLLVNTC AHRDDVVLTC QVEHDGQQAV SKSYALEISA HQKEHGSDIT
361: HEAALAPTAP LLVALLLGPK LLLVVGVSAI YICWKQKA