8.A.23.1.37
Platelet-derived growth factor receptor beta, PDGFRB, a tyrosine-protein kinase that acts as a cell-surface
receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by
PDGFA and PDGFB (Kelly et al. 1991), and plays an essential role in the regulation of
embryonic development, cell proliferation, survival, Ca2+ transport, differentiation,
chemotaxis and migration (Kazlauskas et al. 1991; Vanlandewijck et al. 2015). It has been associated with Primary Familial Brain Calcification (PFBC) (Monfrini et al. 2023).
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| Accession Number: | P09619 |
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| Protein Name: | Platelet-derived growth factor receptor beta |
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| Length: | 1106 |
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| Molecular Weight: | 123968.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
protein |
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1: MRLPGAMPAL ALKGELLLLS LLLLLEPQIS QGLVVTPPGP ELVLNVSSTF VLTCSGSAPV
61: VWERMSQEPP QEMAKAQDGT FSSVLTLTNL TGLDTGEYFC THNDSRGLET DERKRLYIFV
121: PDPTVGFLPN DAEELFIFLT EITEITIPCR VTDPQLVVTL HEKKGDVALP VPYDHQRGFS
181: GIFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITLMCIVIGN
241: EVVNFEWTYP RKESGRLVEP VTDFLLDMPY HIRSILHIPS AELEDSGTYT CNVTESVNDH
301: QDEKAINITV VESGYVRLLG EVGTLQFAEL HRSRTLQVVF EAYPPPTVLW FKDNRTLGDS
361: SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGHYTMRAFH EDAEVQLSFQ LQINVPVRVL
421: ELSESHPDSG EQTVRCRGRG MPQPNIIWSA CRDLKRCPRE LPPTLLGNSS EEESQLETNV
481: TYWEEEQEFE VVSTLRLQHV DRPLSVRCTL RNAVGQDTQE VIVVPHSLPF KVVVISAILA
541: LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL
601: VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP
661: HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKRRP PSAELYSNAL
721: PVGLPLPSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP
781: SAPERTCRAT LINESPVLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV
841: KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG
901: GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER
961: LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RLPGFHGLRS PLDTSSVLYT AVQPNEGDND
1021: YIIPLPDPKP EVADEGPLEG SPSLASSTLN EVNTSSTISC DSPLEPQDEP EPEPQLELQV
1081: EPEPELEQLP DSGCPAPRAE AEDSFL