8.A.23.1.38
BDNF/NT-3 growth factors receptor, ofNKRK2 or TrkB, of 822 aas and 1 N-terminal TMS. It is a receptor
tyrosine kinase involved in the development and the maturation of the
central and the peripheral nervous systems through regulation of neuron
survival, proliferation, migration, differentiation, and synapse
formation and plasticity. It is a receptor for BDNF/brain-derived neurotrophic factor and
NTF4/neurotrophin-4. Alternatively, it can bind NTF3/neurotrophin-3
which is less efficient in activating the receptor but regulates neuron
survival through NTRK2 (Haniu et al. 1995, Yeo et al. 2004). Upon ligand-binding, it undergoes homodimerization, autophosphorylation and activation (Yeo et al. 2004).
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| Accession Number: | Q16620 |
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| Protein Name: | BDNF/NT-3 growth factors receptor |
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| Length: | 822 |
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| Molecular Weight: | 91999.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP
61: NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI
121: NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES
181: SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM
241: NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
301: WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT
361: LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST
421: DVTDKTGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKGPASV ISNDDDSASP
481: LHHISNGSNT PSSSEGGPDA VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL
541: KRELGEGAFG KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI
601: VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ SQMLHIAQQI
661: AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD VYSTDYYRVG GHTMLPIRWM
721: PPESIMYRKF TTESDVWSLG VVLWEIFTYG KQPWYQLSNN EVIECITQGR VLQRPRTCPQ
781: EVYELMLGCW QREPHMRKNI KGIHTLLQNL AKASPVYLDI LG