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8.A.23.1.4
Canalicular bile acid transporter (C-BAT) ecto-ATPase (GP110)

Accession Number:P16573
Protein Name:ECTO aka C-BAT aka GP110
Length:519
Molecular Weight:57264.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

RefSeq: NP_001029032.1    NP_001029033.1    NP_001029034.1    NP_113943.1   
Entrez Gene ID: 81613   
Pfam: PF00047    PF07686   
KEGG: rno:81613   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005515 F:protein binding
GO:0007155 P:cell adhesion
GO:0043406 P:positive regulation of MAP kinase activity
GO:0007165 P:signal transduction

References (10)

[1] “Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. The primary structure of the ecto-ATPase is similar to that of the human biliary glycoprotein I.”  Lin S.-H.et.al.   2527235
[2] “Different isoforms and stock-specific variants of the cell adhesion molecule C-CAM (cell-CAM 105) in rat liver.”  Edlund M.et.al.   8504806
[3] “Molecular cloning and expression of a new rat liver cell-CAM105 isoform. Differential phosphorylation of isoforms.”  Culic O.et.al.   1637321
[4] “The cytoplasmic domain of C-CAM is required for C-CAM-mediated adhesion function: studies of a C-CAM transcript containing an unspliced intron.”  Cheung P.H.et.al.   8240240
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The cell adhesion molecule Cell-CAM 105 is an ecto-ATPase and a member of the immunoglobulin superfamily.”  Aurivillius M.et.al.   2141577
[7] “Characterisation of the ATP-dependent taurocholate-carrier protein (gp110) of the hepatocyte canalicular membrane.”  Becker A.et.al.   8513803
[8] “The rat liver ecto-ATPase is also a canalicular bile acid transport protein.”  Sippel C.J.et.al.   8420979
[9] “pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms.”  Najjae S.M.et.al.   8380406
[10] “Immunochemical characterization of two isoforms of rat liver ecto-ATPase that show an immunological and structural identity with a glycoprotein cell-adhesion molecule with Mr 105,000.”  Lin S.-H.et.al.   1831973

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELASARLLR GQIPWRGLLL TASLLTYWSP LTTAQVTVDA VPPNVVEESS VLLLTHNLPQ 
61:	EFQVFYWYKV TTTGLNSEIA RYIRSSNTSQ TEPAYSGRVT IYSNGSLFFQ NVNKTDEGPY 
121:	TLSVIDKQFN PIQTSVQFRV YPALQKPNVT GNNSNPMEGE PFVSLMCEPY TNNTSYLWSR 
181:	NGESLSEGDR VTFSEGNRTL TLLNVRRTDK GYYECEARNP ATFNRSDPFN LDVIYGPDAP 
241:	VISPPDIYLH QGSNLNLSCH ADSNPPAQYF WLINEKLQTS SQELFISNIT TNNSGTYACF 
301:	VNNTVTGLSR TTVKNITVFE PVTQPSIQIT NTTVKELGSV TLTCFSKDTG VSVRWLFNSQ 
361:	SLQLTDRMTL SQDNSTLRID PIKREDAGDY QCEISNPVSF RISHPIKLDV IPDPTQGNSG 
421:	LSEGAIAGIV IGSVAGVALI AALAYFLYSR KTGGGSDHRD LTEHKPSTSS HNLGPSDDSP 
481:	NKVDDVSYSV LNFNAQQSKR PTSASSSPTE TVYSVVKKK