8.A.23.1.41
Macrophage colony-stimulating factor 1 receptor, CSF1R or FMS of 972 aas and 2 or 3 TMSs, one at the N-terminus, one large peak of hydrophobicity at ~ residue 520, and a much smaller peak at residue 650. It is a tyrosine-protein kinase that acts as a cell-surface
receptor for CSF1 and IL34 and plays an essential role in the regulation
of survival, proliferation and differentiation of hematopoietic
precursor cells, especially mononuclear phagocytes, such as macrophages
and monocytes. It promotes the release of proinflammatory chemokines in
response to IL34 and CSF1, and thereby plays an important role in innate
immunity and in inflammatory processes. It regulates bone resorption and is required for normal bone
and tooth development. It is also required for normal male and female fertility,
and for normal development of milk ducts. It promotes cancer cell invasion and activates several
signaling pathways in response to ligand binding, including the ERK1/2
and the JNK pathways (Wei et al. 2010, Guo et al. 2019). High expression of CSF-1R predicts poor prognosis in colon adenocarcinoma (Wang et al. 2022).
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| Accession Number: | P07333 |
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| Protein Name: | Macrophage colony-stimulating factor 1 receptor |
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| Length: | 972 |
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| Molecular Weight: | 107984.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MGPGVLLLLL VATAWHGQGI PVIEPSVPEL VVKPGATVTL RCVGNGSVEW DGPPSPHWTL
61: YSDGSSSILS TNNATFQNTG TYRCTEPGDP LGGSAAIHLY VKDPARPWNV LAQEVVVFED
121: QDALLPCLLT DPVLEAGVSL VRVRGRPLMR HTNYSFSPWH GFTIHRAKFI QSQDYQCSAL
181: MGGRKVMSIS IRLKVQKVIP GPPALTLVPA ELVRIRGEAA QIVCSASSVD VNFDVFLQHN
241: NTKLAIPQQS DFHNNRYQKV LTLNLDQVDF QHAGNYSCVA SNVQGKHSTS MFFRVVESAY
301: LNLSSEQNLI QEVTVGEGLN LKVMVEAYPG LQGFNWTYLG PFSDHQPEPK LANATTKDTY
361: RHTFTLSLPR LKPSEAGRYS FLARNPGGWR ALTFELTLRY PPEVSVIWTF INGSGTLLCA
421: ASGYPQPNVT WLQCSGHTDR CDEAQVLQVW DDPYPEVLSQ EPFHKVTVQS LLTVETLEHN
481: QTYECRAHNS VGSGSWAFIP ISAGAHTHPP DEFLFTPVVV ACMSIMALLL LLLLLLLYKY
541: KQKPKYQVRW KIIESYEGNS YTFIDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT
601: AFGLGKEDAV LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTHGGPVL
661: VITEYCCYGD LLNFLRRKAE AMLGPSLSPG QDPEGGVDYK NIHLEKKYVR RDSGFSSQGV
721: DTYVEMRPVS TSSNDSFSEQ DLDKEDGRPL ELRDLLHFSS QVAQGMAFLA SKNCIHRDVA
781: ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK WMAPESIFDC VYTVQSDVWS
841: YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF APKNIYSIMQ ACWALEPTHR
901: PTFQQICSFL QEQAQEDRRE RDYTNLPSSS RSGGSGSSSS ELEEESSSEH LTCCEQGDIA
961: QPLLQPNNYQ FC