8.A.23.1.51
General control nonderepressible kinase 2 of 1699 aas and 0-2 TMSs. Also called eukaryotic translation initiation factor 2-alpha kinase, Gcn-2. Serine/threonine-protein kinase which phosphorylates the alpha subunit
of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to
its inactivation and thus to a rapid reduction of translational
initiation and repression of global protein synthesis.
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| Accession Number: | D0Z5N4 |
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| Protein Name: | Eukaryotic translation initiation factor 2-alpha kinase gcn-2 |
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| Length: | 1699 |
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| Molecular Weight: | 191260.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Substrate |
protein |
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1: MTKENQIVLD ERVKENQHLQ EEEKLALDAV YLNQITYIKA HWHVWVPTNC HILLKALDSC
61: FLNGDPLGKS KLSVILHVKC SEDYPQRKPA VDLLDPQGLS KEDVQNLLTI LRQMADTWEG
121: CVVIAELAHR VREFLTDHTP RPAGSFHDDM LANKVRTEAE KQRKRLDTEQ KELELLEEEM
181: RQRNAIEMEK TLNGTRQENE TRIIGGRRIV VLSNMPNTQL LISEWTFRFS SNRNPAEGKR
241: KDFAPFLQKL DAVYNEIQKL CEIKGLDQNL VEYAFVHLQK ISVSPDQILI QLNVAQKIFS
301: SEENMQDTYE LIVQKSNLLR LLAAQAICGL RYLHEASMTH KHLTLGSVWT RNSTGDCVFR
361: FSDFGSMGPL LDLVKMFGDI CSGKYVARDE DKEKEYDRRR KDLFQLGTLL DGLILATRGS
421: TYSRVPTPVE GNQNTGTNLL GNFIAKCQEA KNIDQLVEDP FLKEECQSES ENIFTPFGGA
481: MSPDGRMLAD NVIIRVLGRG GFGDVVLVRN KMDSTDYAIK RIPLNAKSDK LNRKIAKEAK
541: FFAKLNHPNM VRYYYAWAED LIPIVEETSD DDSSLGAVPI PGKEKIGKKG KLKTGKSLED
601: KENKANLGGG DSLMPMNLRG LVKDHSIGVD AKEWSTPFGK PEGPKCASRM RQSKRSTPSG
661: GLKHLSECSS DDEDDDDSSE IDWDAESEEV EDEESDDSDE EDEDDGERLV QLNTETSTGA
721: DSVFERSTAD EDVVFTAESE DLNAKRRESI ELMEINTTTT SKSKLAIDVV PVRKPRILCI
781: QMEYCDRATL RQYIDENHCF NAPTEVWRIF SEVLCGLKYM HDMAMIHRDI KPLNIFLTSQ
841: NGVKIGDFGL ATLEAMSSKG KIVGGAAEKS TSIEAMLSPN GVKSKGSDVH QTRDIGTQLY
901: MAPELFVDEL VHKAPYTSKI DIYSAGVVLF EMFYRPLPPS MDRVSTLNNL RDDIKIPSDF
961: GAGLAAPMAG LARRTVEKML QRNPDERPTA DDLLNDEDLP MHTKEDATFR NLCEKVIKKR
1021: DGRMNAWLLD KQFKEEVPTS LNYCYDVDIC LERAKYNNRE VLVETLRAEF CKILKIHSFE
1081: KLHTHTLMPV STALAAASVR TKPVEVLDRS GVPVALPMDL RQNFVRFCVR NSVQRMKRFN
1141: FGRVYSQTSA NGHPHERWEC CVDCIGPQCS SPSLEAELLL VACEMMIGSL PGMKFTLKIG
1201: HAQLIEAQIR HLKLSDDVRA ELLDALHLIS VSDRPHSHKE KMDMLTPKIG AKAANIITKL
1261: LIPVEDNFGA FKEKVACFRK KLKVDAARVL VDKAIRDLEE IVGTFKFCRT EAIEQISIVY
1321: DSQTCYRPRT FGDGLLFQIQ VEKPSTIANN KRGRRQNVLA GGRYDSALLR ERHPRDFVYE
1381: IPLCISGFGV AMDVVSQIRD SINKSANIPK TPQNHCKVLI CSMVQPDGSN LITQKFELAK
1441: KLWSMGIEAD VFHIPVDDLE SLTEHRNRAS ITHILAVYNT LNEVICKTET SSETMDVDSA
1501: ISSVWRGVQA LDGQSIHMTP CGGGPISSIS TPGEAHHHDD HHPGTPVIAS KCFRSSVSTT
1561: VATTSIRPIS ATVANLNVIL VTSADRFHKV MKEKKRVESQ VRNHLTEFVA HFTSKTRIEV
1621: LVCDIPADVI KKIVSELTKT SSEAEIDKLF DQLIQKHGKV DLSPLRRQFH ITLNGISTGS
1681: AQVAILFYRQ SDNFYRYLV