8.A.23.1.58
Transmembrane and immunoglobulin domain-containing protein 1, TMIGD(1), isoform 2 precursor of 218 aas with 1 N-terminal TMS plus one possible TMS at about residue 120. The functions of TMIGD1 have been reviewed and include those of a tumor supressor and an adhesion receptor (Thüring et al. 2023; Mu et al. 2022). Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223 (Chang et al. 2023).  Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease (Zhou et al. 2023).