8.A.23.1.64
CD146, MCAM or MUC18 of 646 aas with 2 TMSs, N- and C-terminal. It plays a role in cell adhesion, and in cohesion of the endothelial
monolayer at intercellular junctions in vascular tissues (Anfosso et al. 2001). Its expression
may allow melanoma cells to interact with cellular elements of the
vascular system, thereby enhancing hematogeneous tumor spread. It could be
an adhesion molecule active in neural crest cells during embryonic
development. It acts as a surface receptor that triggers tyrosine
phosphorylation of FYN and PTK2/FAK1, and a transient increase in the
intracellular calcium concentration (Johnson et al. 1993). It is a possible drug target for pheochromocytomas and paragangliomas (PPGLs), rare neuroendocrine tumors (Vit et al. 2023).
|
| Accession Number: | P43121 |
|---|
| Protein Name: | Cell surface glycoprotein MUC18 |
|---|
| Length: | 646 |
|---|
| Molecular Weight: | 71607.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
|---|
| Substrate |
|
|---|
1: MGLPRLVCAF LLAACCCCPR VAGVPGEAEQ PAPELVEVEV GSTALLKCGL SQSQGNLSHV
61: DWFSVHKEKR TLIFRVRQGQ GQSEPGEYEQ RLSLQDRGAT LALTQVTPQD ERIFLCQGKR
121: PRSQEYRIQL RVYKAPEEPN IQVNPLGIPV NSKEPEEVAT CVGRNGYPIP QVIWYKNGRP
181: LKEEKNRVHI QSSQTVESSG LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE
241: VTVPVFYPTE KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNPS TREAEEETTN
301: DNGVLVLEPA RKEHSGRYEC QGLDLDTMIS LLSEPQELLV NYVSDVRVSP AAPERQEGSS
361: LTLTCEAESS QDLEFQWLRE ETGQVLERGP VLQLHDLKRE AGGGYRCVAS VPSIPGLNRT
421: QLVNVAIFGP PWMAFKERKV WVKENMVLNL SCEASGHPRP TISWNVNGTA SEQDQDPQRV
481: LSTLNVLVTP ELLETGVECT ASNDLGKNTS ILFLELVNLT TLTPDSNTTT GLSTSTASPH
541: TRANSTSTER KLPEPESRGV VIVAVIVCIL VLAVLGAVLY FLYKKGKLPC RRSGKQEITL
601: PPSRKSELVV EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH