8.A.23.1.65
eIF-2-alpha kinase, GCN2, of 1648 aas and an undetermined number of putative TMSs, possibly none. It is a metabolic-stress-sensing protein kinase that phosphorylates the alpha
subunit of eukaryotic translation initiation factor 2
(EIF2S1/eIF-2-alpha) in response to low amino acid availability (Lehman et al. 2015).
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| Accession Number: | Q9QZ05 |
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| Protein Name: | eIF-2-alpha kinase GCN2 |
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| Length: | 1648 |
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| Molecular Weight: | 186487.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
protein |
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1: MAGGRGASGR GRAEPQESYS QRQDHELQAL EAIYGSDFQD LRPDARGRVR EPPEINLVLY
61: PQGLAGEEVY VQVELQVKCP PTYPDVVPEI ELKNAKGLSN ESVNLLKSHL EELAKKQCGE
121: VMIFELAHHV QSFLSEHNKP PPKSFHEEML ERQAQEKQQR LLEARRKEEQ EQREILHEIQ
181: RRKEEIKEEK KRKEMAKQER LEITSLTNQD YASKRDPAGH RAAAILHGGS PDFVGNGKAR
241: TYSSGRSRRE RQYSVCSGEP SPGSCDILHF SVGSPDQLMV HKGRCVGSDE QLGKVVYNAL
301: ETATGSFVLL HEWVLQWQKM GPCLTSQEKE KIDKCKRQIQ GAETEFSSLV KLSHPNIVRY
361: FAMNSREEED SIVIDILAEH VSGISLATHL SHSGPVPAHQ LRKYTAQLLA GLDYLHSNSV
421: VHKVLSASSV LVDAEGTVKI TDYSISKRLA DICKEDVFEQ ARVRFSDSAL PYKTGKKGDV
481: WRLGLLLLSL SQGQECGEYP VTIPSDLPAD FQDFLKKCVC LDDKERWSPQ QLLKHSFINP
541: QPKLPLVEQS PEDSGGQDYI ETVIPSNQLP SAAFFSETQK QFSRYFIEFE ELQLLGKGAF
601: GAVIKVQNKL DGCCYAVKRI PINPASRHFR RIKGEVTLLS RLHHENIVRY YNAWIERHER
661: PAVPGTPPPD CTPQAQDSPA TCGKTSGDTE ELGSVEAAAP PPILSSSVEW STSAERSTST
721: RFPVTGQDSS SDEEDEDERD GVFSQSFLPA SDSDSDIIFD NEDENSKSQN QDEDCNQKDG
781: SHEIEPSVTA EAVHYLYIQM EYCEKSTLRD TIDQGLFRDT SRLWRLFREI LDGLAYIHEK
841: GMIHRDLKPV NIFLDSDDHV KIGDFGLATD HLAFTAEGKQ DDQAGDGVIK SDPSGHLTGM
901: VGTALYVSPE VQGSTKSAYN QKVDLFSLGI IFFEMSYHPM VTASERIFVL NQLRDPTSPK
961: FPDDFDDGEH TKQKSVISWL LNHDPAKRPT AMELLKSELL PPPQMEESEL HEVLHHTLAN
1021: IDGKAYRTMM SQIFCQHISP AIDYTYDSDI LKGNFLIRTA KIQQLVCETI VRVFKRHGAV
1081: QLCTPLLLPR NRQIYEHNEA ALFMDHSGML VMLPFDLRVP FARYVARNNI LNLKRYCIER
1141: VFRPRKLDRF HPKELLECAF DIVTSTTNSS LPTAETIYTI YEIIQEFPAL QERNYSIYLN
1201: HTMLLKAILL HCGIPEDKLS QVYVILYDAV TEKLTRREVE AKFCNLSLSS NSLCRLYKFI
1261: EQKGDLQDLT PTINSLIKQK TGVAQLVKYS LKDLEDVVGL LKKLGVKLQV SINLGLVYKV
1321: QQHTGIIFQF LAFSKRRQRV VPEILAAGGR YDLLIPKFRG PQTVGPVPTA VGVSIAIDKI
1381: FAAVLNMEEP VTVSSCDLLV VSVGQMSMSR AINLTQKLWT AGITAEIMYD WSQSQEELQE
1441: YCRHHEITYV ALVSDKEGSH VKVKSFEKER QTEKRVLESD LVDHVMQKLR TKVGDERNFR
1501: DASDNLAVQT LKGSFSNASG LFEIHGTTVV PNVIVLAPEK LSASTRRRHE IQVQTRLQTT
1561: LANLHQKSSE IEILAVDLPK ETILQFLSLE WDADEQAFNT TVKQLLSRLP KQRYLKLVCD
1621: EIYNIKVEKK VSVLFLYSYR DDYYRILF