8.A.23.1.7
Fibroblast growth factor receptor 1, FGFR1, of822 aas and 2 TMSs, one N-terminal and one central. FGFR1 is a tyrosine-protein kinase that acts as
cell-surface receptor for fibroblast growth factors and plays an
essential role in the regulation of embryonic development, cell
proliferation, differentiation and migration. Required for normal
mesoderm patterning and correct axial organization during embryonic
development, normal skeletogenesis and normal development of the
gonadotropin-releasing hormone (GnRH) neuronal system (Haenzi and Moon 2017).
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| Accession Number: | P11362 |
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| Protein Name: | Fibroblast growth factor receptor 1 |
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| Length: | 822 |
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| Molecular Weight: | 91868.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
61: VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD
121: ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS
181: SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN
241: HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
301: GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE
361: ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS
421: IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL
481: GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK
541: HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
601: VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG
661: RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD
721: KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF
781: PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR