8.A.23.2.6
CD16A (FcγRIIIA, FCGR3A, FCG3, FCGR3, IGFR3) antiinflamatory protein of 254 aas and 2 TMSs, N- and C-terminal (Ben Mkaddem et al. 2014). It is a receptor for the Fc region of IgG. It binds complexed
or aggregated IgG and also monomeric IgG and mediates antibody-dependent
cellular cytotoxicity (ADCC) and other antibody-dependent responses,
such as phagocytosis (Ferrara et al. 2011, Mizushima et al. 2011).
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| Accession Number: | P08637 |
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| Protein Name: | Low affinity immunoglobulin gamma Fc region receptor III-A |
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| Length: | 254 |
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| Molecular Weight: | 29089.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
|
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1: MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW
61: FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE
121: EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN
181: VSSETVNITI TQGLAVSTIS SFFPPGYQVS FCLVMVLLFA VDTGLYFSVK TNIRSSTRDW
241: KDHKFKWRKD PQDK