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8.A.23.3.1
TMEM25 of 366 aas and up to 4 TMSs, scattered throughout the protein. The expression of the Tmem25 is strongly influenced by glutamate ionotropic receptor kainate type subunit 4, and it is primarily localized to late endosomes in neurons (Zhang et al. 2019). The effects of TMEM25 on neuronal excitability are likely mediated by N-methyl-D-aspartate receptors. TMEM25 affects the expression of the NR2B subunit and interacts with NR2B; both colocalize to late endosome compartments. TMEM25 induces acidification changes in lysosome compartments and accelerates the degradation of NR2B, and TMEM25 expression is decreased in brain tissues from patients with epilepsy and epileptic mice. TMEM25 overexpression attenuated the behavioral phenotypes of epileptic seizures, whereas TMEM25 downregulation exerted the opposite effect (Zhang et al. 2019).

Accession Number:Q86YD3
Protein Name:Transmembrane protein 25
Length:366
Molecular Weight:39285.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Late endosome1
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MALPPGPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF TCRVAGGPGT 
61:	PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR AQHELNCSLQ DPRSGRSANA 
121:	SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV LFALVRANPP ANVTWIDQDG PVTVNTSDFL 
181:	VLDAQNYPWL TNHTVQLQLR SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV 
241:	AAGLALGTLV GFSTLVACLV CRKEKKTKGP SRHPSLISSD SNNLKLNNVR LPRENMSLPS 
301:	NLQLNDLTPD SRAVKPADRQ MAQNNSRPEL LDPEPGGLLT SQGFIRLPVL GYIYRVSSVS 
361:	SDEIWL