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8.A.23.4.1
Intercellular adhesion molecule 1, ICAM-1 or ICAM1, of 532 aas and 2 TMSs, N- and C-terminal. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups (Hayashi et al. 2001; van Buul et al. 2007). STAT3-dependent transcriptional regulation of ICAM-1, an endothelial transmembrane protein, regulates vascular permeability in endothelial cells (Wang et al. 2020).  

Accession Number:P05362
Protein Name:Intercellular adhesion molecule 1
Length:532
Molecular Weight:57825.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST SCDQPKLLGI 
61:	ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP 
121:	LPSWQPVGKN LTLRCQVEGG APRANLTVVL LRGEKELKRE PAVGEPAEVT TTVLVRRDHH 
181:	GANFSCRTEL DLRPQGLELF ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD 
241:	GLFPVSEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE 
301:	TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL GPRAQLLLKA 
361:	TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ 
421:	AWGNPLPELK CLKDGTFPLP IGESVTVTRD LEGTYLCRAR STQGEVTRKV TVNVLSPRYE 
481:	IVIITVVAAA VIMGTAGLST YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP