8.A.23.4.1
Intercellular adhesion molecule 1, ICAM-1 or ICAM1, of 532 aas and 2 TMSs, N- and C-terminal. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups (Hayashi et al. 2001; van Buul et al. 2007). STAT3-dependent transcriptional regulation of ICAM-1, an endothelial transmembrane protein, regulates vascular permeability in endothelial cells (Wang et al. 2020). Martin et al. 2023 reviewed the role of ICAM-1 during both autoimmunity and islet graft rejection to understand the mechanism(s) leading to islet beta-cell death and dysfunction that results from insufficient circulating quantities of insulin to control glucose homeostasis.
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| Accession Number: | P05362 |
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| Protein Name: | Intercellular adhesion molecule 1 |
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| Length: | 532 |
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| Molecular Weight: | 57825.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST SCDQPKLLGI
61: ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP
121: LPSWQPVGKN LTLRCQVEGG APRANLTVVL LRGEKELKRE PAVGEPAEVT TTVLVRRDHH
181: GANFSCRTEL DLRPQGLELF ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD
241: GLFPVSEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE
301: TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL GPRAQLLLKA
361: TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ
421: AWGNPLPELK CLKDGTFPLP IGESVTVTRD LEGTYLCRAR STQGEVTRKV TVNVLSPRYE
481: IVIITVVAAA VIMGTAGLST YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP