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8.A.23.5.1
Programmed cell death 1 ligand 1, PDL1, CD274, B7H1, PDCD1L1, or PDCD1LG1, of 290 aas and 2 TMSs, one N-terminal and one C-terminal. It plays a role in induction of immune tolerance to self. It plays a critical role in induction and maintenance of immune tolerance to self (Freeman et al. 2000, Burr et al. 2017, Mezzadra et al. 2017). As a ligand for the inhibitory receptor PDCD1/PD-1, it modulates the activation threshold of T-cells and limits T-cell effector responses. Several forms of PD-L1 exist expressed on the plasma membrane (mPD-L1), at the surface of secreted cellular exosomes (exoPD-L1), in cell nuclei (nPD-L1), or as a circulating, soluble protein (sPD-L1) (Bailly et al. 2021). The membrane, exosomal and soluble forms of PD-L1 are parts of the highly dynamic PD-1/PD-L1 signaling pathway.    

Accession Number:Q9NZQ7
Protein Name:Programmed cell death 1 ligand 1
Length:290
Molecular Weight:33275.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Endomembrane system1 / Single-pass type I membrane protein2
Substrate

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FASTA formatted sequence
1:	MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME 
61:	DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VYRCMISYGG 
121:	ADYKRITVKV NAPYNKINQR ILVVDPVTSE HELTCQAEGY PKAEVIWTSS DHQVLSGKTT 
181:	TTNSKREEKL FNVTSTLRIN TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH 
241:	LVILGAILLC LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET