TCDB is operated by the Saier Lab Bioinformatics Group

8.A.233.  The Scotin (Shisa-5) Family 

Scotin (Shisa-5) can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. Scotin is a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane (Bourdon et al. 2002).  proposed that SCOTIN impedes the ER-to-Golgi transport through its ability to form biomolecular condensates at the ER membrane (Kim et al. 2023).

References associated with 8.A.233 family:

Bourdon, J.C., J. Renzing, P.L. Robertson, K.N. Fernandes, and D.P. Lane. (2002). Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J. Cell Biol. 158: 235-246. 12135983
Kim, N., T.H. Kim, C. Kim, J.E. Lee, M.G. Kang, S. Shin, M. Jung, J.S. Kim, J.Y. Mun, H.W. Rhee, S.Y. Park, Y. Shin, and J.Y. Yoo. (2023). Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport. Dev Cell 58: 1950-1966.e8. 37816329