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8.A.32.1.2
β-secretase 2 of 518 aas and as many as 5 TMSs in a 2 (N-terminal) + 3 (C-terminal) TMS arrangement, BACE2. BACE2 regulates TMEM38B (TRIC-B; TC# 1.A.62.1.3). TMEM38B, whose expression is dependent on BACE2, modulates calcium release from the ER in ocular melanoma, and inhibition of the BACE2/TMEM38B axis may trigger exhaustion of intracellular calcium release while inhibiting tumor progression (He et al. 2021). It is responsible for the proteolytic processing of the amylHe et al. 2021). It is responsible for the proteolytic processing of the amyloid precursor protein (APP) (Yan et al. 1999).

Accession Number:Q9Y5Z0
Protein Name:Beta-secretase 2
Length:518
Molecular Weight:56180.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
2EWY   3ZKG   3ZKI   3ZKM   3ZKN   3ZKQ   3ZKS   3ZKX   3ZL7   3ZLQ   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG TPAERHADGL 
61:	ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG 
121:	TPHSYIDTYF DTERSSTYRS KGFDVTVKYT QGSWTGFVGE DLVTIPKGFN TSFLVNIATI 
181:	FESENFFLPG IKWNGILGLA YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA 
241:	GSGTNGGSLV LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA 
301:	IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET PWSYFPKISI 
361:	YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP STNALVIGAT VMEGFYVIFD 
421:	RAQKRVGFAA SPCAEIAGAA VSEISGPFST EDVASNCVPA QSLSEPILWI VSYALMSVCG 
481:	AILLVLIVLL LLPFRCQRRP RDPEVVNDES SLVRHRWK