8.A.32.1.2
β-secretase 2 of 518 aas and as many as 5 TMSs in a 2 (N-terminal) + 3 (C-terminal) TMS arrangement, BACE2. BACE2 regulates TMEM38B (TRIC-B; TC# 1.A.62.1.3). TMEM38B, whose expression is dependent on BACE2,
modulates calcium release from the ER in ocular melanoma, and inhibition
of the BACE2/TMEM38B axis may trigger exhaustion of intracellular
calcium release while inhibiting tumor progression (He et al. 2021). It is responsible for the proteolytic processing of the amylHe et al. 2021). It is responsible for the proteolytic processing of the amyloid precursor protein (APP) (Yan et al. 1999).
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| Accession Number: | Q9Y5Z0 |
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| Protein Name: | Beta-secretase 2 |
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| Length: | 518 |
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| Molecular Weight: | 56180.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG TPAERHADGL
61: ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG
121: TPHSYIDTYF DTERSSTYRS KGFDVTVKYT QGSWTGFVGE DLVTIPKGFN TSFLVNIATI
181: FESENFFLPG IKWNGILGLA YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA
241: GSGTNGGSLV LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA
301: IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET PWSYFPKISI
361: YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP STNALVIGAT VMEGFYVIFD
421: RAQKRVGFAA SPCAEIAGAA VSEISGPFST EDVASNCVPA QSLSEPILWI VSYALMSVCG
481: AILLVLIVLL LLPFRCQRRP RDPEVVNDES SLVRHRWK