TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.34.1.1









Endophilin A1 (BAR-domain, SH3-domain containing GRB2-like protein 2 (Endophilin 1 or A1; SH3-domain protein 2A))
Eukaryota
Metazoa
Endophilin A1 of Mus musculus (Q62420)
8.A.34.1.2









The neuronal regulatory Src homology 3 (SH3) and cysteine-rich domain-containing protein, STAC, of 402 aas and 0 TMSs (Suzuki et al. 1996). 

Eukaryota
Metazoa
STAC of Homo sapiens
8.A.34.1.3









SH3 and cysteine-rich domain-containing protein 3, STAC3 of 364 aas. Excitation-contraction (EC) coupling in skeletal muscle requires functional and mechanical coupling between L-type voltage-gated calcium channels (CaV1.1) and the ryanodine receptor (RyR1), and STAC3 is an essential protein for EC coupling. It is part of a group of three proteins that can bind and modulate L-type voltage-gated calcium channels (Wong King Yuen et al. 2017).

 

Eukaryota
Metazoa
STAC3 of Homo sapiens
8.A.34.1.4









Endophilin-B1 of 365 aas; also called Bif-1.  Acts with dynamin 2 (DNM2; P50570; similar to 9.A.63.1.1) to cause membrane fission of vesicles/tubular structures containing the Atg9 protein of 839 aas and 6 - 8 TMSs (9.a.15.2.1; Takahashi et al. 2016).

Eukaryota
Metazoa
Endophilin-B1 of Homo sapiens
8.A.34.1.5









CD2-associated protein, CD2AP, of 639 aas.  It acts as an adapter protein between membrane proteins and the actin cytoskeleton (Kirsch et al. 1999). Several proteins including podocin (TC# 8.A.21.1.2), nephrin (8.A.23.1.33), CD2AP, and TRPC6 (1.A.4.1.5) form a macromolecular assembly that constitutes the "slit-diaphragm" that functions like a tight junction in podocytes (Mulukala et al. 2020).

 

Eukaryota
Metazoa
CD2AP of Homo sapiens
8.A.34.2.1









Reduced viability upon starvation protein, Rvs161 (also called Amphiphysen-like lipid raft protein, BAR domain protein, and BAR adaptor protein). (Muller et al, 2003; Ren et al., 2006)
Eukaryota
Fungi
Rvs161 of Saccharomyces cerevisiae (P25343)
8.A.34.3.1









TSPO accessory protein, TSPOAP, of 1857 aas and possibly 0 TMSs. It may have 2 TMSs centered near residue 1010. It is a cytoplasmic protein  associated with its mitochondrial transmembrane protein partner translocator protein (TSPO; TC# 9.A.24) (Suthar et al. 2021). TSPO and TSPOAP1 interact via voltage-dependent anion-selective channels (VDAC1/2/3). A heat map analysis indicated that TSPOAP1 has critical roles in inflammatory, neuroinflammatory, psychiatric, and metabolic diseases and disorders, as well as cancer, and it interacts with several other proteins in the cell as well (Suthar et al. 2021).

Eukaryota
Opisthokonta
TSPOAP1 of Homo sapiens