8.A.34.1.5
CD2-associated protein, CD2AP, of 639 aas. It acts as an adapter protein between membrane proteins and the actin cytoskeleton (Kirsch et al. 1999). Several proteins including podocin (TC# 8.A.21.1.2), nephrin (8.A.23.1.33), CD2AP, and TRPC6 (1.A.4.1.5) form a macromolecular assembly that constitutes the "slit-diaphragm" that functions like a tight junction in podocytes (Mulukala et al. 2020).
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| Accession Number: | Q9Y5K6 |
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| Protein Name: | CD2-associated protein |
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| Length: | 639 |
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| Molecular Weight: | 71451.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE
61: TEFKDDSLPI KRERHGNVAS LVQRISTYGL PAGGIQPHPQ TKNIKKKTKK RQCKVLFEYI
121: PQNEDELELK VGDIIDINEE VEEGWWSGTL NNKLGLFPSN FVKELEVTDD GETHEAQDDS
181: ETVLAGPTSP IPSLGNVSET ASGSVTQPKK IRGIGFGDIF KEGSVKLRTR TSSSETEEKK
241: PEKPLILQSL GPKTQSVEIT KTDTEGKIKA KEYCRTLFAY EGTNEDELTF KEGEIIHLIS
301: KETGEAGWWR GELNGKEGVF PDNFAVQINE LDKDFPKPKK PPPPAKAPAP KPELIAAEKK
361: YFSLKPEEKD EKSTLEQKPS KPAAPQVPPK KPTPPTKASN LLRSSGTVYP KRPEKPVPPP
421: PPIAKINGEV SSISSKFETE PVSKLKLDSE QLPLRPKSVD FDSLTVRTSK ETDVVNFDDI
481: ASSENLLHLT ANRPKMPGRR LPGRFNGGHS PTHSPEKILK LPKEEDSANL KPSELKKDTC
541: YSPKPSVYLS TPSSASKANT TAFLTPLEIK AKVETDDVKK NSLDELRAQI IELLCIVEAL
601: KKDHGKELEK LRKDLEEEKT MRSNLEMEIE KLKKAVLSS