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8.A.45.1.1
The single-pass Essential MCU REgulator membrane protein with aspartate-rich tail of 107 aas, EMRE or MICU1/2 (Sancak et al. 2013).  Also called the chromosome 22 ORF32 protein.  Functions to interlink MICU1 and 2 to MCU in the mitorchondrial uniporter complex (TC# 1.A.77 (Vais et al. 2020). In amoeba and fungi, MCU homologs are sufficient to form a functional calcium channel, whereas human MCU exhibits a strict requirement for EMRE for conductance.  EMRE directly interacts with human MCU at its transmembrane domains as well as the 10 aa interaction domain (MacEwen et al. 2020). EMRE stabilizes the EDD of MCU, permitting both channel opening and calcium conductance, consistent with recently published structures of MCU-EMRE (MacEwen et al. 2020). See the family description of MCU (1.A.77) for more deetails.

Accession Number:Q9H4I9
Protein Name:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial
Length:107
Molecular Weight:11441.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion1
Substrate NONE

Cross database links:

Structure:
6K7X   6K7Y   6O58   6O5B   6WDN   6WDO   6XJV   6XJX     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASGAARWLV LAPVRSGALR SGPSLRKDGD VSAAWSGSGR SLVPSRSVIV TRSGAILPKP 
61:	VKMSFGLLRV FSIVIPFLYV GTLISKNFAA LLEEHDIFVP EDDDDDD