8.A.51.1.2
The inactive dipeptidyl peptidase or prolyl oligopeptidase, DPP10 (DPPY, DPRP-3, DPL2, DPPIV  or DPR3) is of 798 aas with 1 N-terminal TMS. It preferentially binds to Kv4 channel proteins to increase current density and alter channel gating (Ren et al. 2005; Zagha et al. 2005). DPP10 also forms complexes with itself and with DPPX in the absence of Kv4 channels. DPP10 mRNA is abundantly expressed in nodose and dorsal root ganglia, suggesting that DPP10 participates in controlling airway reactivity and mechanosensation. The region from the N-terminus to the end of the TMS mediates its association with the channel, whereas the S1-S2 portion of the channel is sufficient for complex formation. This N-terminal portion of DPP10 also confers all the gating effects produced by the peptidase homologue (Ren et al. 2005). DPP10 has an N-terminal DPPIV_N domain and a C-terminal abhydrolase domain. It is an inactivating modulator of Kv4 channels and the Kv1.4 channel (Kuo et al. 2017). DPP10 and KChIP2b (Q9NS61; TC# 8.a.82.2.4) both modulate Kv4.3 inactivation, but their primary effects are on different inactivation states (Kuo et al. 2017).