Barttin of 320 aas and 2 N-terminal TMSs.  Barttin is an auxillary subunit of the α-subunit of the K⁺-dependent chloride channels, designated CLC-K, BSND and BART (see TC# 2.A.49.2.4-5) (Wojciechowski et al. 2015). Barttin stabilizes the ClC-K/barttin complex, promotes its insertion into the surface membrane, and turns the pore-forming subunits into a conductive state. The N-terminal domain of barttin is essential for its activity (Wojciechowski et al. 2018). The protein is associated with Bartter's disease (Elrharchi et al. 2018).