8.A.54.1.7
Integrin alpha-11, α-11, α11, of 1188 aas and 4 TMSs, one N-terminal, two close to each other in a central location in the protein, and one C-terminal. It is a receptor for collagen (Gullberg and Lundgren-Akerlund 2002). Mechanical tension and integrin beta-1 regulate fibroblast functions (Eckes et al. 2006). Cells contain at least two types of collagen receptors: integrins and discoidin domain receptors (DDRs) (Yeh et al. 2012).
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| Accession Number: | Q9UKX5 |
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| Protein Name: | Integrin alpha-11 |
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| Length: | 1188 |
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| Molecular Weight: | 133470.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MDLPRGLVVA WALSLWPGFT DTFNMDTRKP RVIPGSRTAF FGYTVQQHDI SGNKWLVVGA
61: PLETNGYQKT GDVYKCPVIH GNCTKLNLGR VTLSNVSERK DNMRLGLSLA TNPKDNSFLA
121: CSPLWSHECG SSYYTTGMCS RVNSNFRFSK TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE
181: VQHFLINILK KFYIGPGQIQ VGVVQYGEDV VHEFHLNDYR SVKDVVEAAS HIEQRGGTET
241: RTAFGIEFAR SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL
301: GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF SLEGTNKNET
361: SFGLEMSQTG FSSHVVEDGV LLGAVGAYDW NGAVLKETSA GKVIPLRESY LKEFPEELKN
421: HGAYLGYTVT SVVSSRQGRV YVAGAPRFNH TGKVILFTMH NNRSLTIHQA MRGQQIGSYF
481: GSEITSVDID GDGVTDVLLV GAPMYFNEGR ERGKVYVYEL RQNLFVYNGT LKDSHSYQNA
541: RFGSSIASVR DLNQDSYNDV VVGAPLEDNH AGAIYIFHGF RGSILKTPKQ RITASELATG
601: LQYFGCSIHG QLDLNEDGLI DLAVGALGNA VILWSRPVVQ INASLHFEPS KINIFHRDCK
661: RSGRDATCLA AFLCFTPIFL APHFQTTTVG IRYNATMDER RYTPRAHLDE GGDRFTNRAV
721: LLSSGQELCE RINFHVLDTA DYVKPVTFSV EYSLEDPDHG PMLDDGWPTT LRVSVPFWNG
781: CNEDEHCVPD LVLDARSDLP TAMEYCQRVL RKPAQDCSAY TLSFDTTVFI IESTRQRVAV
841: EATLENRGEN AYSTVLNISQ SANLQFASLI QKEDSDGSIE CVNEERRLQK QVCNVSYPFF
901: RAKAKVAFRL DFEFSKSIFL HHLEIELAAG SDSNERDSTK EDNVAPLRFH LKYEADVLFT
961: RSSSLSHYEV KPNSSLERYD GIGPPFSCIF RIQNLGLFPI HGMMMKITIP IATRSGNRLL
1021: KLRDFLTDEA NTSCNIWGNS TEYRPTPVEE DLRRAPQLNH SNSDVVSINC NIRLVPNQEI
1081: NFHLLGNLWL RSLKALKYKS MKIMVNAALQ RQFHSPFIFR EEDPSRQIVF EISKQEDWQV
1141: PIWIIVGSTL GGLLLLALLV LALWKLGFFR SARRRREPGL DPTPKVLE