TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.54.1.1









Integrin α-1 (AITGA1) or CD49 of 1179 aas and 2 TMSs (N- and C-termini).  Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.  Plays a role in sperm-egg fusion as a receptor, but not as the fusogen (Sabetian et al. 2014).

Eukaryota
Metazoa, Chordata
CD49 of Homo sapiens
8.A.54.1.2









Integrin α-6 of 1130 aas.  Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (Pawar et al. 2007).

Eukaryota
Metazoa, Chordata
ITGAE of Homo sapiens
8.A.54.1.3









Cochlin of 550 aas and 1 N-terminal TMS, possibly with more TMSs in the rest of the protein.  Shows similarity with a protein of TC# 2.A.74.1.6 as well as 8.A.54.1.1.  binds to ZCTL2 (SLC44A2), a putative choline transporter (TC# 2.A.92.1.2) (Kommareddi et al. 2007). It may be associated with Meniere's Disease (Lopez-Escamez et al. 2018).

Eukaryota
Metazoa, Chordata
Cochlin of Homo sapiens
8.A.54.1.4









Integrin alpha5, ITGA5, of 1048 aas.  Functions with beta subunits such as beta1 (TC# 9.B.87.1.8) (Häussinger and Kordes 2017). It is a potential biomarker of head and neck squamous cell carcinoma (Zou et al. 2019). Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins (Short et al. 2005).

Eukaryota
Metazoa, Chordata
Integrin α5 of Homo sapiens
8.A.54.1.5









Integrin alpha7 of 1181 aas and 2 TMSs, N- and C-terminal. Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers (Tran et al. 2007). Signaling via this protein regulates connexin 43, M-cadherin, and myoblast fusion (McClure et al. 2019).

 

Eukaryota
Metazoa, Chordata
Integrin α7 of Homo sapiens
8.A.54.1.6









Transmembrane integrin α-L, ITGAL, of 1170 aas and 2 TMSs, N- and C-terminal.  These proteins may play a role in amoeboid swimming, propelled by molecular paddling in lymphocytes (Aoun et al. 2020). Leukocytes can swim, and efficient propulsion is by a rearward and inhomogeneous treadmilling of the cell external membrane. Thus, a molecular paddling by transmembrane proteins linked to and advected by the actin cortex is responsible for motility, whereas freely diffusing transmembrane proteins hinder swimming. Continuous paddling is enabled by a combination of external treadmilling and selective recycling by internal vesicular transport of cortex-bound transmembrane proteins (Aoun et al. 2020).

Eukaryota
Metazoa, Chordata
ITGAL of Homo sapiens
8.A.54.1.7









Integrin alpha-11, α-11, α11, of 1188 aas and 4 TMSs, one N-terminal, two close to each other in a central location in the protein, and one C-terminal. It is a receptor for collagen (Gullberg and Lundgren-Akerlund 2002). Mechanical tension and integrin beta-1 regulate fibroblast functions (Eckes et al. 2006). Cells contain at least two types of collagen receptors: integrins and discoidin domain receptors (DDRs) (Yeh et al. 2012).

Eukaryota
Metazoa, Chordata
Integrin α11 of Homo sapiens
8.A.54.1.8









Alpha 5 integrin of 1049 aas and 2 TMSs, N- and C-terminal. It forms a dimer with the Beta1 integrin of 200 aas and 0 TMSs. This essential heterodimeric transmembrane protein mediates the communication between the extracellular matrix and the cytosolic cytoskeleton in processes of cell adhesion and migration (Dransart et al. 2022).

Eukaryota
Metazoa, Chordata
α5/β1 integrin of Homo sapiens
α5 integrin, P08640
β1 integrin, O14713