TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.56.1.1









Wntless, Evenness interrupted or Sprinter (Wls; Evi; Srt) protein of 594 aas and 9 TMSs (Bartscherer et al. 2006).  Wls directs wg and wnt secretion (Franch-Marro et al. 2008; Hausmann et al. 2007). Wls forms a complex with Procupine (PORCN), and the two proteins have dissimilar functions in the overall secretion process  with Wls being the only one of these proteins to function directly in sercetion (Galli et al. 2016).

Eukaryota
Metazoa
Wls of Drosophila melanogaster (Fruit fly)
8.A.56.1.2









Wntless (Wls) protein of 541 aas and 8 TMSs.  Regulates Wnt protein sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (Xiao et al. 2015).

Eukaryota
Metazoa
Wnt of Homo sapiens
8.A.56.1.3









Uncharacterized protein of 538 aas and 9 probable TMSs in a 1 + 8 arrangement.

Eukaryota
Metazoa
UP of Aethina tumida (small hive beetle)
8.A.56.1.4









Uncharacterized putative Wnt-binding factor required for Wnt secretion; pfam06664, of 534 aas and up to 11 TMSs.

UP of Nilaparvata lugens
8.A.56.2.1









Uncharacterized protein of 181 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Firmicutes
UP of Lactobacillus oris
8.A.56.2.2









Uncharacterized protein of 177 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Firmicutes
UP of Enterococcus saccharolyticus
8.A.56.2.3









Uncharacterized DUF3278 domain-containing protein of 169 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Firmicutes
UP of Vagococcus fluviali
8.A.56.3.1









Uncharacterized molecular chaperone-like protein, GroL, of 616 aas with 5 C-terminal TMSs.

Bacteria
Proteobacteria
GroL of Pseudomonas syringae