TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.56.1.1









Wntless, Evenness interrupted or Sprinter (Wls; Evi; Srt) protein of 594 aas and 9 TMSs (Bartscherer et al. 2006).  Wls directs wg and wnt secretion (Franch-Marro et al. 2008; Hausmann et al. 2007). Wls forms a complex with Procupine (PORCN), and the two proteins have dissimilar functions in the overall secretion process  with Wls being the only one of these proteins to function directly in sercetion (Galli et al. 2016).  

Eukaryota
Metazoa, Arthropoda
Wls of Drosophila melanogaster (Fruit fly)
8.A.56.1.2









Wntless (Wls) protein of 541 aas and 8 TMSs in a 1 + 7 TMS arrangement.  Regulates Wnt protein sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (Xiao et al. 2015).

Eukaryota
Metazoa, Chordata
Wls of Homo sapiens
8.A.56.1.3









Uncharacterized protein of 538 aas and 9 probable TMSs in a 1 + 8 arrangement.

Eukaryota
Metazoa, Arthropoda
UP of Aethina tumida (small hive beetle)
8.A.56.1.4









Uncharacterized putative Wnt-binding factor required for Wnt secretion; pfam06664, of 534 aas and up to 11 TMSs.

Metazoa, Arthropoda
UP of Nilaparvata lugens
8.A.56.1.5









TMEM181 of 612 aas and 8 TMSs in a 1 + 7 TMS arrangement. It mediates the action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression levels of TMEM181 are rate-limiting for intoxication (Carette et al. 2009).

Eukaryota
Metazoa, Chordata
TMEM181 of Homo sapiens
8.A.56.1.6









Rhodopsin-1, isoform A, light sensor of 547 aas and 8 TMSs in a 1 + 7 TMS arrangement (Gaspar et al. 2023).

Eukaryota
Metazoa, Arthropoda
Rhodopsin-1 of Drosophila melanogaster
8.A.56.2.1









Uncharacterized protein of 181 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Bacillota
UP of Lactobacillus oris
8.A.56.2.2









Uncharacterized protein of 177 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Bacillota
UP of Enterococcus saccharolyticus
8.A.56.2.3









Uncharacterized DUF3278 domain-containing protein of 169 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Bacillota
UP of Vagococcus fluviali
8.A.56.3.1









Uncharacterized molecular chaperone-like protein, GroL, of 616 aas with 4 or 5 C-terminal TMSs. If 4, they may be present in a 2 + 2 TMS arrangement like members of TC subfamily 8.A.56.2.

Bacteria
Pseudomonadota
GroL of Pseudomonas syringae
8.A.56.3.2









RDD family domain-containing protein of 396 aas and 4 possible TMSs in a 2 + 2 TMS arrangement.

Bacteria
Pseudomonadota
RDD domain protein of Alcanivorax sp. MD8A
8.A.56.3.3









J domain-containing protein of 426 aas and 2 C-terminal TMSs.

Bacteria
Bacillota
J domain protein of Bacillus cereus