8.A.58.1.2
Interferon-induced transmembrane protein 2, IFITM2, is of 132 aas with 2 TMSs. Exosome-mediated transport of IFITM2 to dendridic cells inhibits IFNalpha (IFNα) pathway activation and blocks anti-hepatitis B virus (HBV) efficacy of exogenous IFNalpha (Shi et al. 2019). IFITMs are members of the dispanin/CD225 family that act as broad viral inhibitors by preventing viral-to-cellular membrane fusion (Zhong et al. 2022).
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| Accession Number: | Q01629 |
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| Protein Name: | Interferon-induced transmembrane protein 2 |
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| Length: | 132 |
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| Molecular Weight: | 14632.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass membrane protein2 |
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| Substrate |
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1: MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE TSVPDHVVWS
61: LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGIFMTILL
121: IIIPVLVVQA QR