8.A.58.2.14
SynDIG4, Prrt1 or Ng5 of 306 aas and 2 TMSs. Associates with and regulates both AMPA and GluA1 receptors (Kirk et al. 2016). It regulates basal and plasticity-induced AMPA receptor trafficking (Troyano-Rodriguez et al. 2019). SynDIG4 and PRRT1 act as typical AMPAR auxiliary proteins, while
PRRT2 functions at presynaptic sites to regulate synaptic vesicle
dynamics and is the causative gene for neurological paroxysmal disorders
in humans (Dίaz 2021).
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| Accession Number: | O35449 |
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| Protein Name: | Proline-rich transmembrane protein 1 |
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| Length: | 306 |
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| Molecular Weight: | 31389.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
|
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1: MSSEKSGLPD SVPHTSPPPY NAPQPPAEPP IPPPQTAPSS HHHHHHHYHQ SGTATLPRLG
61: AGGLASAAAS AQRGPSSSAT LPRPPHHAPP GPAAGAPPPG CATLPRMPPD PYLQETRFEG
121: PLPPPPPAAA APPPPAPAPT AQAPGFVVPT HAGAVGTLPL GGYVAPGYPL QLQPCTAYVP
181: VYPVGTPYAG GTPGGPGVTS TLPPPPQGPG LALLEPRRPP HDYMPIAVLT TICCFWPTGI
241: IAIFKAVQVR TALARGDLVS AEIASREARN FSFISLAVGI AAMVLCTILT VVIIIAAQHH
301: ENYWDP