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8.A.63.1.1
Sigma-1 non-opioid intracellular receptor SGMR-1, OPRS1, SRBP, AAG8) of 223 aas and 2 or 3 TMSs.  It influences the activities of various channels and carriers including L-type Ca2+ channels (Tchedre et al. 2008) and the dopamine transporter, DAT (2.A.22.1.3; Hong et al. 2017). Sigma-1 receptors play a negative modulation role on N-type Ca2+ channels involving chaperone-mediated direct interactions (Zhang et al. 2017). The sigma-1 receptor is a theraputic target in retinal disease (Smith et al. 2018). The sigma1R E102Q mutant exhibits an anomalous response to cytosolic calcium levels, altered affinity for target proteins, and a loss of response to regulatory ligands, and these modifications may contribute to the onset of juvenile ALS (Rodríguez-Muñoz et al. 2020). Sigmar1 localizes to mitochondrial membranes and is indispensable for maintaining mitochondrial respiratory homeostasis in cardiomyocytes (Abdullah et al. 2021). It helps to locate endoplasmic reticulum calcium channels, regulates calcium homeostasis, and acts as a molecular chaperone to control cell fate and participate in signal transduction. It plays a role in protecting neurons through a variety of signaling pathways and participates in the regulation of cognition and motor behavior closely related to neurodegenerative diseases. Sig-1R is a target for alleviating Alzheimer's disease and other neurodegenerative diseases (Wu et al. 2021).

Accession Number:Q99720
Protein Name:Sigma non-opioid intracellular receptor 1
Length:223
Molecular Weight:25128.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Nucleus inner membrane1
Substrate

Cross database links:

Structure:
5hk1   5HK2   6DJZ   6DK0   6DK1     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 
61:	LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGRY 
121:	WAEISDTIIS GTFHQWREGT TKSEVFYPGE TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS 
181:	TLAFALADTV FSTQDFLTLF YTLRSYARGL RLELTTYLFG QDP