TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.64.1.1









PIRT (phosphoinositide-interacting protein) of 137 aas and 2 TMSs.  Regulates Trp-CC channels (TC# 1.A.4) (Tang et al. 2015) including TRPM8 (Hilton et al. 2018).  PIRT also regulates the ATP-activated P2X3 channel (TC# 1.A.7.1.6) in bladder cells (Gao et al. 2015). Calmodulin binds to the PIRT C-terminal alpha-helix, and a cholesterol-recognition amino acid consensus (CRAC) domain in the outer leaflet of the first transmembrane helix of PIRT binds to a number of cholesterol-derivatives including cholecalciferol and oxytocin, which explains the role of PIRT in regulating various ion channels (Sisco et al. 2020).

Eukaryota
Metazoa
PIRT of Homo sapiens
8.A.64.1.2









TMEM100 or PIRT of 134 aas and 2 TMSs.

Eukaryota
Metazoa
PIRT of Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
8.A.64.1.3









Uncharacterized protein of 339 aas and 2 TMSs.

Eukaryota
Metazoa
UP of Helobdella robusta (Californian leech)
8.A.64.1.4









Uncharacterized protein of 292 aas and 2 TMSs

Eukaryota
Metazoa
UP of Branchiostoma floridae (Florida lancelet) (Amphioxus)
8.A.64.1.5









Uncharacterized protein of 161 aas and 2 TMSs.

Eukaryota
Metazoa
UP of Capitella teleta (Polychaete worm)
8.A.64.1.6









Uncharacteerized protein of 331 aas and 2 TMSs.

Eukaryota
Fungi
UP of Piriformospora indica
8.A.64.1.7









Pirt of 147 aas and 2 TMSs.

Eukaryota
Metazoa
Pirt of Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
8.A.64.1.8









Transmembrane protein 100, TMEM100 of 134 aas and 2 TMSs. It plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. It is also involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. It is expressed together with these two TRP cannel protein in odontoblasts (Liu et al. 2021).

Eukaryota
Opisthokonta
TMEM100 of Homo sapiens