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8.A.64.1.1
PIRT (phosphoinositide-interacting protein) of 137 aas and 2 TMSs.  Regulates Trp-CC channels (TC# 1.A.4) (Tang et al. 2015) including TRPM8 (Hilton et al. 2018).  PIRT also regulates the ATP-activated P2X3 channel (TC# 1.A.7.1.6) in bladder cells (Gao et al. 2015). Calmodulin binds to the PIRT C-terminal alpha-helix, and a cholesterol-recognition amino acid consensus (CRAC) domain in the outer leaflet of the first transmembrane helix of PIRT binds to a number of cholesterol-derivatives including cholecalciferol and oxytocin, which explains the role of PIRT in regulating various ion channels (Sisco et al. 2020).

Accession Number:P0C851
Protein Name:Phosphoinositide-interacting protein
Length:137
Molecular Weight:15334.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

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FASTA formatted sequence
1:	MTMETLPKVL EVDEKSPEAK DLLPSQTASS LCISSRSESV WTTTPRSNWE IYRKPIVIMS 
61:	VGGAILLFGV VITCLAYTLK LSDKSLSILK MVGPGFLSLG LMMLVCGLVW VPIIKKKQKH 
121:	RQKSNFLRSL KSFFLTR