TCDB is operated by the Saier Lab Bioinformatics Group

8.A.66 The Dystrophin (Dystrophin) Family.

Transmembrane protein CD4 and voltage-dependent Ca2+ channels (VDCC ; TC# 1.A.1.11.28) within neuromuscular synapses and at the surfaces of muscle cells in normal and dystrophin-mutant worms proved to be regulated by dystrophin (Zhan et al. 2014). Dystrophin is involved in modulating the confinement of VDCC within sarcolemmal membrane nanodomains in response to varying tonus of C. elegans body-wall muscles. In humans, the interaction of filamin A (TC# 8.A.66.1.4), a homologue of dystrophin, with the hyperpolarization-activated cyclic nucleotide-gated K+ channel, HCN1 (TC# 1.A.1.5.32), helps to localized HCN1 to specific neuronal areas, and it modulates its channel activity (Gravante et al. 2004).

References associated with 8.A.66 family:

Gravante, B., A. Barbuti, R. Milanesi, I. Zappi, C. Viscomi, and D. DiFrancesco. (2004). Interaction of the pacemaker channel HCN1 with filamin A. J. Biol. Chem. 279: 43847-43853. 15292205
Kakinuma, T., H. Ichikawa, Y. Tsukada, T. Nakamura, and B.H. Toh. (2004). Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. Exp Cell Res 298: 388-398. 15265687
Leyva-Leyva, M., A. Sandoval, R. Felix, and R. González-Ramírez. (2018). Biochemical and Functional Interplay Between Ion Channels and the Components of the Dystrophin-Associated Glycoprotein Complex. J. Membr. Biol. [Epub: Ahead of Print] 29779049
Li, Q., N. Montalbetti, P.Y. Shen, X.Q. Dai, C.I. Cheeseman, E. Karpinski, G. Wu, H.F. Cantiello, and X.Z. Chen. (2005). Alpha-actinin associates with polycystin-2 and regulates its channel activity. Hum Mol Genet 14: 1587-1603. 15843396
Lopez-Escamez, J.A., A. Batuecas-Caletrio, and A. Bisdorff. (2018). Towards personalized medicine in Ménière''s disease. F1000Res 7:. 30430003
Modarres, H.P. and M.R. Mofradt. (2014). Filamin: a structural and functional biomolecule with important roles in cell biology, signaling and mechanics. Mol. Cell Biomech 11: 39-65. 25330623
Nakamura, F., T.P. Stossel, and J.H. Hartwig. (2011). The filamins: organizers of cell structure and function. Cell Adh Migr 5: 160-169. 21169733
Zhan, H., R. Stanciauskas, C. Stigloher, K.K. Dizon, M. Jospin, J.L. Bessereau, and F. Pinaud. (2014). In vivo single-molecule imaging identifies altered dynamics of calcium channels in dystrophin-mutant C. elegans. Nat Commun 5: 4974. 25232639
Zhang, Z., H.A. Ledford, S. Park, W. Wang, S. Rafizadeh, H.J. Kim, W. Xu, L. Lu, V.C. Lau, A.A. Knowlton, X.D. Zhang, E.N. Yamoah, and N. Chiamvimonvat. (2016). Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α-actinin2 and filamin A. J. Physiol. [Epub: Ahead of Print] 27779751