8.A.66 The Dystrophin (Dystrophin) Family.
Transmembrane protein CD4 and voltage-dependent Ca2+ channels (VDCC ; TC# 1.A.1.11.28) within neuromuscular synapses and at the surfaces of muscle cells in normal and dystrophin-mutant worms proved to be regulated by dystrophin (Zhan et al. 2014). Dystrophin is involved in modulating the confinement of VDCC within sarcolemmal membrane nanodomains in response to varying tonus of C. elegans body-wall muscles. In humans, the interaction of filamin A (TC# 8.A.66.1.4), a homologue of dystrophin, with the hyperpolarization-activated cyclic nucleotide-gated K+ channel, HCN1 (TC# 1.A.1.5.32), helps to localized HCN1 to specific neuronal areas, and it modulates its channel activity (Gravante et al. 2004).