8.A.77.1.10
Disintegrin and metalloproteinase domain-containing protein 15, ADAM15 or MDC15, a member of the of 863 aas and 2 TMSs, one N-terminal and the other near the C-terminus of the protein. It is an active metalloproteinase with gelatinolytic and collagenolytic activity, and it plays a role in the wound healing process. It mediates both heterotypic
intraepithelial cell/T-cell interactions and homotypic T-cell
aggregation. It also inhibits beta-1 integrin-mediated cell adhesion and
migration of airway smooth muscle cells (Martin et al. 2002; Charrier et al. 2005; Böhm et al. 2005). Membrane proteins regulated by ADAM15 have been identified using SUSPECS proteomics (Böhm et al. 2005). Membrane proteins regulated by ADAM15 have been identified using SUSPECS proteomics (Calligaris et al. 2023).
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| Accession Number: | Q13444 |
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| Protein Name: | Disintegrin and metalloproteinase domain-containing protein 15 |
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| Length: | 863 |
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| Molecular Weight: | 92959.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endomembrane system1 / Single-pass type I membrane protein2 |
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| Substrate |
protein |
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1: MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
61: LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
121: GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
181: LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
241: EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
301: AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
361: PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
421: AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
481: RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
541: PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
601: ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
661: CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
721: LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
781: KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
841: GIPPLVVPSR PAPPPPTVSS LYL