TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.81.1.1









The S100-A1 protein of 94 aas and 1 C-terminal TMS.  Regulates TRPM1 activity (Jirku et al. 2016) and the ryanodine receptor (Chen and Kudryashev 2020). It is capable of increasing the open probability of RyR1 and may compete with calmodulin (CaM, TC# 8.A.82) for the same binding site on the receptor (Chen and Kudryashev 2020).

Eukaryota
Metazoa, Chordata
S100-A1 of Homo sapiens
8.A.81.1.2









S100-A10 protein of 97 aas and 1 C-terminal TMS.  Interacts with annexin A2 to regulate intracellular trafficking and virus entry (Dziduszko and Ozbun 2013).  It also functions as a linker, tethering certain transmembrane proteins to annexin A2, thereby assisting trafficing to the plasma membrane and anchorage at certain membrane sites (Rescher and Gerke 2008).

Eukaryota
Metazoa, Chordata
S100-A10 of Homo sapiens
8.A.81.1.3









S100-A16 of 103 aas and 1 C-terminal TMS.  Binds one calcium ion per monomer (Sturchler et al. 2006).

Eukaryota
Metazoa, Chordata
  S100-A16 of Homo sapiens
8.A.81.1.4









The S100-B protein of 92 aas. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Eukaryota
Metazoa, Chordata
S100-B of Homo sapiens