8.A.82.1.11
Calcium binding protein 1, CABP1, of 370 aas and 0 TMSs. It modulates the calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (Haynes et al. 2004) and inhibits agonist-induced intracellular calcium signaling (Zhou et al. 2005). It also enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (Lee et al. 2002). It causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but  it has an opposite effect on channel function (Zhou et al. 2004). It suppresses the calcium-dependent inactivation of CACNA1D and inhibits TRPC5 channels (Kinoshita-Kawada et al. 2005) while preventing NMDA receptor-induced cellular degeneration. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels (Giese et al. 2023).