8.A.82.1.12
Calpain-1 (two subunits): CPNL1 (catalytic subunit)/CPNS1 (small subunit) of 725 and 268 aas, respectively. Mitochondrial calpain-1 truncates ATP synthase beta subunit (Chukai et al. 2025). Calpains cleave proteins in a calcium concentration-dependent manner,
modulating their intracellular functions. Calpain-1, a member of the
calpain family, is localized in the cytosol and mitochondria.
Mitochondrial calpain-1 induces mitochondrial dysfunction and apoptosis
by cleaving its substrate.
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| Accession Number: | P07384 |
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| Protein Name: | Calpain-1 catalytic subunit |
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| Length: | 714 |
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| Molecular Weight: | 81890.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
protein |
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1: MSEEIITPVY CTGVSAQVQK QRARELGLGR HENAIKYLGQ DYEQLRVRCL QSGTLFRDEA
61: FPPVPQSLGY KDLGPNSSKT YGIKWKRPTE LLSNPQFIVD GATRTDICQG ALGDCWLLAA
121: IASLTLNDTL LHRVVPHGQS FQNGYAGIFH FQLWQFGEWV DVVVDDLLPI KDGKLVFVHS
181: AEGNEFWSAL LEKAYAKVNG SYEALSGGST SEGFEDFTGG VTEWYELRKA PSDLYQIILK
241: ALERGSLLGC SIDISSVLDM EAITFKKLVK GHAYSVTGAK QVNYRGQVVS LIRMRNPWGE
301: VEWTGAWSDS SSEWNNVDPY ERDQLRVKME DGEFWMSFRD FMREFTRLEI CNLTPDALKS
361: RTIRKWNTTL YEGTWRRGST AGGCRNYPAT FWVNPQFKIR LDETDDPDDY GDRESGCSFV
421: LALMQKHRRR ERRFGRDMET IGFAVYEVPP ELVGQPAVHL KRDFFLANAS RARSEQFINL
481: REVSTRFRLP PGEYVVVPST FEPNKEGDFV LRFFSEKSAG TVELDDQIQA NLPDEQVLSE
541: EEIDENFKAL FRQLAGEDME ISVKELRTIL NRIISKHKDL RTKGFSLESC RSMVNLMDRD
601: GNGKLGLVEF NILWNRIRNY LSIFRKFDLD KSGSMSAYEM RMAIESAGFK LNKKLYELII
661: TRYSEPDLAV DFDNFVCCLV RLETMFRFFK TLDTDLDGVV TFDLFKWLQL TMFA