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8.A.82.2.2
Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4).  These proteins have N-terminal variants due to the presence of multiple start sites (Jerng and Pfaffinger 2014). Novel long interspersed element-1 (L1) retrotransposon insertions in several genes associated with seizures/epilepsy, including a de novo somatic L1 retrotransposition in KCNIP4, have been identified (Doyle et al. 2021).

Accession Number:Q6PIL6
Protein Name:Kv channel-interacting protein 4
Length:250
Molecular Weight:28729.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 80333   
KEGG: hsa:80333   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005509 F:calcium ion binding
GO:0005267 F:potassium channel activity
GO:0005244 F:voltage-gated ion channel activity

References (6)

[1] “Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.”  Morohashi Y.et.al.   11847232
[2] “Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.”  Holmqvist M.H.et.al.   11805342
[3] “Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.”  Pruunsild P.et.al.   16112838
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNVRRVESIS AQLEEASSTG GFLYAQNSTK RSIKERLMKL LPCSAAKTSS PAIQNSVEDE 
61:	LEMATVRHRP EALELLEAQS KFTKKELQIL YRGFKNECPS GVVNEETFKE IYSQFFPQGD 
121:	STTYAHFLFN AFDTDHNGAV SFEDFIKGLS ILLRGTVQEK LNWAFNLYDI NKDGYITKEE 
181:	MLDIMKAIYD MMGKCTYPVL KEDAPRQHVE TFFQKMDKNK DGVVTIDEFI ESCQKDENIM 
241:	RSMQLFENVI