8.A.82.2.5
Calsenilin (KCHIP3, KCNIP3, CSEN, DREAM) of 256 aas and 0 TMSs.  Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (Jerng and Pfaffinger 2008). Interacts with TRPV1 (TC# 1.A.4.2.1) and alleviates inflammatory hyperalgesia (Tian et al. 2018). IQM-266 is a chemical that may allow a better understanding of DREAM physiological role as well as modulation of neuronal I A in pathological processes (Peraza et al. 2019). Overexpression of calsenilin enhances gamma-secretase activity (TC# 4.G.1) (Jo et al. 2005).