8.A.82.2.6
Kv channel-interacting protein, KChIP-1 or KCNIP1 of 227 aas and 0 TMSs. It is a regulatory subunit of Kv4/D (Shal)-type
voltage-gated rapidly inactivating A-type potassium channels. It regulates
channel density and influences inactivation kinetics and the rate of recovery from
inactivation in a calcium-dependent and isoform-specific manner. In
vitro, it modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents and increases the
presence of KCND2 at the cell surface (Wang et al. 2007; An et al. 2000).
|
| Accession Number: | Q9NZI2 |
|---|
| Protein Name: | Kv channel-interacting protein 1 |
|---|
| Length: | 227 |
|---|
| Molecular Weight: | 26817.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Peripheral membrane protein2 |
|---|
| Substrate |
|
|---|
1: MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL EQLEAQTNFT
61: KRELQVLYRG FKNECPSGVV NEDTFKQIYA QFFPHGDAST YAHYLFNAFD TTQTGSVKFE
121: DFVTALSILL RGTVHEKLRW TFNLYDINKD GYINKEEMMD IVKAIYDMMG KYTYPVLKED
181: TPRQHVDVFF QKMDKNKDGI VTLDEFLESC QEDDNIMRSL QLFQNVM