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8.A.82.2.8
Hippocalcin, a Ca2+-binding protein of 193 aas. It may play a role in the regulation of voltage-dependent calcium channels (Helassa et al. 2017). It may also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.  Parkin-null brains show dysregulation of this calcium homeostasis factor as well as ATP1A2 and GNA11, reflected by altered firing of noradrenergic neurons (Key et al. 2019).  Variants in Ano3 (TC# 1.A.17.1.20) and other Ca2+ regulating proteins like hippocalcin have been identified as  causes of dystonia (Ousingsawat et al. 2024).  

Accession Number:P84074
Protein Name:Neuron-specific calcium-binding protein hippocalcin
Length:193
Molecular Weight:22427.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

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Structure:
5G4P   5G58   5M6C     

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FASTA formatted sequence 
1:	MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK IYANFFPYGD 
61:	ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK LMWAFSMYDL DGNGYISREE 
121:	MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 
181:	RLLQCDPSSA SQF