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8.A.82.2.9
Guanylyl cyclase-activating protein 2 of 200 aas, GucA1B or Gcap2. It stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when the free calcium ion concentration is low, and inhibits them when the free calcium ion concentration is elevated. This Ca2+-sensitive regulation of GCs is a key event in the recovery of the dark state of rod photoreceptors following light exposure. It may be involved in the cone photoreceptor response and recovery in bright light. Light activates a G protein signaling cascade, which closes cGMP-gated channels and decreases Ca2+ levels in photoreceptor outer segment because of continuing Ca2+ extrusion by NCKXs (Vinberg et al. 2018).  

Accession Number:Q9UMX6
Protein Name:Guanylyl cyclase-activating protein 2
Length:200
Molecular Weight:23420.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate

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FASTA formatted sequence
1:	MGQEFSWEEA EAAGEIDVAE LQEWYKKFVM ECPSGTLFMH EFKRFFKVTD DEEASQYVEG 
61:	MFRAFDKNGD NTIDFLEYVA ALNLVLRGTL EHKLKWTFKI YDKDGNGCID RLELLNIVEG 
121:	IYQLKKACRR ELQTEQGQLL TPEEVVDRIF LLVDENGDGQ LSLNEFVEGA RRDKWVMKML 
181:	QMDMNPSSWL AQQRRKSAMF