8.A.82.2.9 Guanylyl cyclase-activating protein 2 of 200 aas, GucA1B or Gcap2. It stimulates two retinal guanylyl cyclases (GCs)
GUCY2D and GUCY2F when the free calcium ion concentration is low, and
inhibits them when the free calcium ion concentration is
elevated. This Ca2+-sensitive regulation of
GCs is a key event in the recovery of the dark state of rod photoreceptors
following light exposure. It may be involved in the cone
photoreceptor response and recovery in bright light. Light activates a G protein signaling cascade, which closes cGMP-gated channels and decreases Ca2+ levels in photoreceptor outer segment because of continuing Ca2+ extrusion by NCKXs (Vinberg et al. 2018).
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Accession Number: | Q9UMX6 |
Protein Name: | Guanylyl cyclase-activating protein 2 |
Length: | 200 |
Molecular Weight: | 23420.00 |
Species: | Homo sapiens (Human) [9606] |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Lipid-anchor2 |
Substrate |
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1: MGQEFSWEEA EAAGEIDVAE LQEWYKKFVM ECPSGTLFMH EFKRFFKVTD DEEASQYVEG
61: MFRAFDKNGD NTIDFLEYVA ALNLVLRGTL EHKLKWTFKI YDKDGNGCID RLELLNIVEG
121: IYQLKKACRR ELQTEQGQLL TPEEVVDRIF LLVDENGDGQ LSLNEFVEGA RRDKWVMKML
181: QMDMNPSSWL AQQRRKSAMF