8.A.82.5.2
N-terminal EF-hand calcium-binding protein 1; Neuronal calcium-binding protein 1 of 351 aas and 0 TMSs. Fluoxetine (Flx) is the most commonly used antidepressant to treat major depressive disorder.  A comparative proteomic approach identified proteome changes in the prefrontal cortex (PFC) cytosolic and non-synaptic mitochondria (NSM)-enriched fractions of adult male Wistar rats following chronic social isolation (CSIS), a rat model of depression.  Flx treatment in CSIS rats downregulated protein involved in oxidative phosphorylation, such as complex III and manganese superoxide dismutase, and upregulated vesicle-mediated transport and synaptic signaling proteins in the cytosol, and neuronal calcium-binding protein 1 in NSM (Filipović et al. 2022).