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8.A.83.1.4
Shisa7 of 538 aas and 2 TMSs.  It is a AMPAR modulatory protein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity and memory recall (Schmitz et al. 2017). Shisa7 controls receptor abundance at synapses and speeds up the channel deactivation kinetics. Shisa7 also potently enhances the action of diazepam, a classic benzodiazepine, on GABAARs. Genetic deletion of Shisa7 selectively impairs GABAergic transmission and diminishes the effects of diazepam in mice. Thus, Shisa7 regulates GABAAR trafficking, function, and pharmacology (Han et al. 2019). A kinetic basis for how Shisa7 modifies temporal attributes of GABAergic transmission at the single-channel level has been described (Castellano et al. 2022).

Accession Number:A6NL88
Protein Name:Protein shisa-7
Length:538
Molecular Weight:56214.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell junction1 / Single-pass type I membrane protein2
Substrate

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FASTA formatted sequence
1:	MPALLLLVLL ASSAGQARAR PSNATSAEPA GPLPALLAHL RRLTGALTGG GGAASPGANG 
61:	TRTGPAGGAG AAARAPPPAE LCHGYYDVMG QYDATFNCST GSYRFCCGTC HYRFCCEHRH 
121:	MRLAQASCSN YDTPRWATTP PPLAGGAGGA GGAGGGPGPG QAGWLEGGRT GGAGGRGGEG 
181:	PGGSTAYVVC GVISFALAVG VGAKVAFSKA SRAPRAHRDI NVPRALVDIL RHQAGPGTRP 
241:	DRARSSSLTP GIGGPDSMPP RTPKNLYNTV KTPNLDWRAL PPPSPSLHYS TLSCSRSFHN 
301:	LSHLPPSYEA AVKSELNRYS SLKRLAEKDL DEAYLKRRPL ELPRGTLPLH ALRRPGTGGG 
361:	YRMEAWGGPE ELGLAPAPNP RRVMSQEHLL GDGGRSRYEF TLPRARLVSQ EHLLLSSPEA 
421:	LRQSREHLLS PPRSPALPPD PTARASLAAS HSNLLLGPGG PPTPLRGLPP PSSLHAHHHH 
481:	ALHGSPQPAW MSDAGGGGGT LARRPPFQRQ GTLEQLQFIP GHHLPQHLRT ASKNEVTV