8.A.83.1.5
Shesa-1 (Shisa1) of 269 aas and 1 TMS. It is required for head formation during gastrulation. It functions as an inhibitor for the caudalizing signals wnt and fgf, but does
not inhibit bmp, activin and nodal signaling in the head formating process.
It induces retention of fzd8 in the endoplasmic reticulum and inhibits
trafficking of fzd8 to the cell surface (Yamamoto et al. 2005).
|
| Accession Number: | A2RV66 |
|---|
| Protein Name: | Protein shisa-1 |
|---|
| Length: | 269 |
|---|
| Molecular Weight: | 29184.00 |
|---|
| Species: | Xenopus laevis (African clawed frog) [8355] |
|---|
| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum1 |
|---|
| Substrate |
|
|---|
1: MEFIVLLTVC ALLGLSCGQH GEYCHGWTDS YGIWRPGFQC PERYDPPEAT FCCGSCGLKY
61: CCSTVESRLD QGLCPNEEDL RDGVPSIELP PTVPTYFPFL LVGSIFVSFV ILGSLVGLCC
121: CKCLKPEDDT QVSGPAPIQS RLLDQDPSTD TSRHSSSSSA SMPRPPIGAR PQNLCSLGAE
181: NINLYMNMPP TFPMMGCPQN AQFMHPGTAG PSFMQPPFIN YAVPAEHAII MAPAPYIDAR
241: NCYGQTSNIY CQVPQQNDQT VCSGSPSKC