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8.A.83.1.6
Shisa-2 (Shisa2) of 288 aas and 2 TMSs, an N-terminal targetting signal, and a central TMS, common to other Shisa proteins.  It plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both Fgf and Wnt signaling. It inhibits both Wnt and Fgf signaling through the regulation of protein maturation and cell surface transport of their receptors within the endoplasmic reticulum (Nagano et al. 2006).

Accession Number:Q2WFL8
Protein Name:Protein shisa-2
Length:288
Molecular Weight:31119.00
Species:Xenopus laevis (African clawed frog) [8355]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Single-pass type I membrane protein2
Substrate

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FASTA formatted sequence
1:	MWLEGSPLAV LAAVSFLLSV LAAAQGSGEY CHGWLDAQAV WRDGFQCPER FDGDDSTICC 
61:	GKCELRYCCS SAEARLDQGV CNNDRQQGAP DHNRPDKDSP DSTAVPIYVP FLIVGSVFVA 
121:	FIIVGSLVAI CCCRCLRPKQ EPQQSRAPGS NRLMETIPMI SSASTSRGSS SRQSSTAASS 
181:	SSSANSGARP PPTRSQTNCC LPEGAMNNVY VNMPTNFSVL NCQQATQLVQ HQGQYLHPQF 
241:	VGYAVPHDSV PMTPVPQFID GLQGGYRQMQ SPYPHSNPEQ MMYPAVTV