TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.84.1.1









TMEM59l of 342 aas and 2 TMSs, one N-terminal and one C-terminal.  Plays a role in insulin secretion in β-cells of the pancreas (Kobayashi et al. 2016).

Eukaryota
Metazoa
TMEM59l of Homo sapiens
8.A.84.1.2









Uncharacterized TMM59 protein of 289 aas and 2 TMSs, one N-terminal and one C-terminal TMSs.

Eukaryota
Metazoa
TMM59 protein of Strongylocentrotus purpuratus (Purple sea urchin)
8.A.84.1.3









Uncharacterized protein of 316 aas and 2 TMSs, N- and C-terminal.

Eukaryota
Metazoa
UP of Rhipicephalus pulchellus
8.A.84.1.4









TMEM59, isoform 1 of 324 aas and 1 or 2 TMSs. TMEM59 or Dendritic cell factor 1 (DCF1) modulates both O- and N-glycosylation of proteins as well as cell surface expression and secretion of the amyloid precursor protein (Ullrich et al. 2010). It also potentiates Wnt signaling by promoting signalosome formation (Gerlach et al. 2018). Finally, it is localized to mitochondria, endosomes, lysosomes, endoplasmic reticulum, and proteasome. It regulates neural stem cell differentiation and dendritic spine formation (Chen et al. 2018). A role for the TMEM59 gene in the hearing process, and mutations in this gene give rise to deafness (Mahfood et al. 2021).

Eukaryota
Metazoa
TMEM59 of Homo sapiens