| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.92.1.1 | G-protein α, β, and γ subunits. Guanine nucleotide-binding proteins (G proteins) are modulators or transducers in various transmembrane signaling systems including transporters (channels and carriers) (see Family description). G protein subunit beta1 plays a role in regulating transmembrane signal transduction, but it also facilitates influenza A virus replication by promoting the nuclear import of the RNA polymerase subunit, PB2 (Zheng et al. 2022). .
| Eukaryota |
Metazoa, Chordata | G-protein α, β, and γ subunits of Homo sapiens |
|
8.A.92.1.2 | G-protein complex with subunits α, β, γ1 and γ2. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (Mudgil et al. 2009). | Eukaryota |
Viridiplantae, Streptophyta | G-protein heterotrimeric complex of Arabidopsis thaliana (Mouse-ear cress) |
|
8.A.92.1.3 | G-protein subunits α, β1, β2 and γ. The exchange of GDP for GTP on the G protein alpha subunit alters its interaction with the G protein beta subunit, leading to dissociation of the G protein beta-gamma dime. The dissociated subunits activate downstream effectors. | Eukaryota |
Fungi, Ascomycota | G-protein subunits α, β, and γ of Saccharomyces cerevisiae (Baker's yeast) |
|
8.A.92.1.4 | Receptor of activated protein C kinase 1 of 317 aas and 0 TMSs. Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. It is nvolved in PKC-dependent translocation of ADAM12 to the cell membrane and promotes ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. It is required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. It regulates internalization of the muscarinic receptor CHRM2 and promotes apoptosis by increasing oligomerization of BAX while disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. It inhibits TRPM6 channel activity and regulates cell surface expression of some GPCRs. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (Ikebuchi et al. 2009). | Eukaryota |
Metazoa, Chordata | Receptor of Homo sapiens |
|
8.A.92.1.5 | Guanine nucleotide-binding protein, subunit alpha-11, GNA11 of 359 aas. It is a modulator or transducers of various transmembrane signaling systems. It may alter the firing of noradrenergic neurons (Key et al. 2019).
| Eukaryota |
Metazoa, Chordata | GNA11 of Homo sapiens |
|
8.A.92.1.6 | Uncharacterized protein of 842 aas and 1 N-terminal TMS. | Eukaryota |
Fungi, Ascomycota | UP of Botryotinia calthae |
|
8.A.92.1.7 | Beta2-adrenaline receptor, β2AR or GNB2, of 340 aas (Hilger et al. 2020). It is 91% identical to GNB1 (TC# 8.A.92.1.1). This protein seems to consist of several internal WD40 repeats of about 45 aas. | Eukaryota |
Metazoa, Chordata | GNB2 of Homo sapiens |
|
8.A.92.1.8 | NACHT domain-containing protein of 1406 aas and 1 central TMS. | Bacteria |
Chloroflexota | NACHT domain protein of Chloroflexi bacterium |
|
8.A.92.1.9 | SEC12-like protein 1 isoform X1 of 388 aas and one C-terminal TM | Eukaryota |
Viridiplantae, Streptophyta | SEC12 of Camellia sinensis |
|
8.A.92.1.10 | SEC12 of 417 aas and 3 TMSs, one N-terminal and two near the C-terminus. | Eukaryota |
Metazoa, Chordata | SEC12 of Homo sapiens |
|
8.A.92.1.11 | Apoptotic protease-activating factor 1, APAF-1, of 1248 aas. Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis (Hu et al. 1999, Ogawa et al. 2003). Physiological concentrations of calcium ions negatively affect the assembly of apoptosome by inhibiting nucleotide exchange in the monomeric form. | Eukaryota |
Metazoa, Chordata | APAF-1 of Homo sapiens |
|
8.A.92.1.12 | Katanin p80 WD40 hydrophilic repeat-containing subunit B1 homologue of 823 aas and 2 - 3 N-terminal TMSs plus 2-3 possible C-terminal TMSs. May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. This protein has at least 4 repeats of about 42 aas (WD40). The protein is an AAA ATPase which targets centrosomes (Hartman et al. 1998). p80 katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein (McNally et al. 2000). | Eukaryota |
Viridiplantae, Streptophyta | Katanin of Arabidopsis thaliana (Mouse-ear cress) |
|
8.A.92.1.13 | Dmx-like protein 2, DMXL2 or Rabconnectin-3, of 3036 aas. It is a component of intercellular desmosome junctions and plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. It also functions as an effector in the TP53-dependent apoptotic pathway. DMXL2, a gene encoding the rabconnectin-3α vesicular protein, is present in human subjects with mental retardation and neuroendocrine impairment of reproduction (Wahab et al. 2017). Rabconnectin-3 complexes of higher eukaryotes regulate acidification of organelles such as lysosomes and endosomes by facilitating V-ATPase assembly (Jaskolka et al. 2021).
| Eukaryota |
Metazoa, Chordata | DMXL2 of Homo sapiens |
|
8.A.92.1.14 | Cell division cycle protein 20 homolog of 499 aas and 0 TMSs. The CDC20-APC/C complex positively regulates the
formation of synaptic vesicle clustering at active zone to the
presynaptic membrane in postmitotic neurons (Yang et al. 2009). CDC20 is differentially expressed in glioma (Xu et al. 2020). | Eukaryota |
Metazoa, Chordata | CDC20 of Homo sapiens |
|
8.A.92.1.15 | Heteromeric 7 TMS glucose receptors coupled with two large G-proteins, Ras1 and Ras2 of 309 and 3322 aas, respectively, both with 1 N-terminal TMS. One subunit is called the guanine nucleotide-binding protein, alpha-2 subunit, Gpa2 of 449 aas and 6 - 8 TMSs, and the other is called the guanine nucleotide binding protein, GPR1, of 961 aas and 6 - 8 TMSs. They comprise a hetero-tri- or tetra-meric guanine nucleotide-binding protein (G protein) complex, involved in glucose-induced cAMP signaling. These two cognate transmembrane G-protein receptors bind to each other, which sense extracellular carbon sources, and activate cAMP-PKA signaling to govern diploid pseudohyphal differentiation and haploid invasive growth. The G protein beta-mimic proteins, GPB1 (Q08886) and GPB2 (P39717) inhibit GPA2-GPR1 coupling, probably to reduce signaling in the absence of glucose (Versele et al. 1999; Harashima and Heitman 2005). The S. cerevisiae Ras proteins, amoung other things, modulate the activity of the adenylate cyclase catalytic subunit and therefore alter the biosynthesis of cyclic-AMP. A multi-omics analysis of multiple glucose-sensing receptor systems in yeast has appeared (Li et al. 2022).
| Eukaryota |
Fungi, Ascomycota | Gpr1/Gpa2 with Ras1 and/or Ras2 of Saccharomyces cerevisiae |
|
8.A.92.1.16 | WD repeat-containing protein 47, WDR47, of 919 aas and 0 TMSs. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery (Guardia et al. 2021). | Eukaryota |
Metazoa, Chordata | WDR47 of Homo sapiens |
|
8.A.92.1.17 | FBXL20 protein of 436 aas and 1 N-terminal TMS. An N-terminal region is similar in sequence to that of TC# 8.A.92.1.6. It promotes synaptic impairment in depression disorder by degrading vesicle-associated proteins (Wang et al. 2024). | Eukaryota |
Metazoa, Chordata | FBXL20 of Homo sapiens |