8.B.10.2.3 Toxin LyeTx 1 of 26 aas. It has antimicrobial activity against the Gram-positive
bacterium, S. aureus (MIC=3.79 µM), the Gram-negative bacterium, E. coli (MIC=7.81 µM) and the yeasts, C. krusei (MIC=26.3 µM) and C. neoformans (MIC=13.2 µM). It also has hemolytic activity against rabbit erythrocytes and forms
pores in lipid bilayers in vitro; pore formation is reduced when
cholesterol is present in the bilayers (Santos et al. 2010). The x-ray structure is known (6CL3_A).
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Accession Number: | C0HJU9 |
Protein Name: | Toxin LyeTx 1 |
Length: | 25 |
Molecular Weight: | 2834.00 |
Species: | Lycosa erythrognatha (Wolf spider) [332789] |
Location1 / Topology2 / Orientation3: |
Secreted1 |
Substrate |
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1: IWLTALKFLG KNLGKHLAKQ QLAKL